不同麻醉用药对老年恶性肿瘤患者围手术期血液流变学的影响分析  

Impact analysis on perioperative blood rheology of different anesthetic drugs in elderly malignant tumor patients

作　　者：李月鹏[1] 刘洪涛[1] 张喜林[1] 

机构地区：[1]中国石油天然气集团公司中心医院麻醉科,廊坊065000

出　　处：《中国肿瘤临床与康复》2013年第6期582-584,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的观察异丙酚和异氟醚对老年恶性肿瘤患者围手术期血液流变学的影响。方法对60例恶性肿瘤根治术患者进行临床分组观察,根据采用不同的麻醉药物,分为观察组和对照组,每组各30例。观察组患者麻醉药物为异丙酚,对照组患者麻醉药物为异氟醚。观察两组患者麻醉前(T0)、麻醉诱导插管后(T1)、手术结束前10 min(T2)、手术后拔管(T3)4个时间点的血液流变学指标的变化。结果两组患者高切变率全血黏度(Hηb)、中切变率全血黏度(Mηb)以及低切变率全血黏度(Lηb)在T1～T3均较T0有明显的下降,尤以观察组患者降低更为明显(P<0.05)。观察组患者收缩压(SBP)、舒张压(DBP)以及心率(HR)在T1～T2时迅速下降,在T3时恢复到基线水平,与对照组比较,差异有统计学意义(P<0.05)。结论异丙酚对患者血流动力学影响较小,是老年恶性肿瘤患者手术理想的麻醉药物。Objective To observe the influence of perioperative blood rheology of propofol and isoflurane in elderly malignant tumor patients.Methods 60 patients with malignant tumor patients were divived into two groups and observed,observation group with anesthetic propofol,control group with anesthetic isoflurane.Observed before anesthesia（T0）,after the induction of anesthesia intubation（T1）,10 min before the end of surgery（T2）,extubation after the operation,four time points（T3） change of blood rheology indexes of two groups.Results Two groups of patients＇ whole blood high shear rate viscosity eta b（Hηb）medium shear rate of whole blood viscosity（Mηb）and low shear rate of whole blood viscosity（Lηb）in T1 and T3 were significantly decreased than in T0,especially in the observation group decreased more significantly（P0.05）.Observation group of systolic blood pressure（SBP）,diastolic blood pressure（DBP） and heart rate（HR） drops rapidly when T1,T2,returned to baseline at T3,compared with control group,the difference was statistically significant（P0.05）.Conclusions The effect of propofol on hemodynamics in patients with small,is the ideal anesthetic in elderly patients with malignant tumor surgery.

关 键 词：异丙酚 异氟醚 恶性肿瘤 围手术期 血液流变学 

分 类 号：R614[医药卫生—麻醉学]