贵州省2010年五个点结核病流行病学抽样调查细菌学结果分析  

Bacteriological analysis and epidemiological survey of tuberculosis in five places of Guizhou province in 2010

作　　者：袁薇[1] 张铭[1] 陈依江[1] 陈慧娟[1] 李杨[1] 潘建敏[1] 周华[1] 

机构地区：[1]贵州省疾病预防控制中心,贵阳550004

出　　处：《中国卫生检验杂志》2013年第6期1586-1589,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的:分析结核病流行病学调查细菌学检查结果,为评价贵州省结核病流行现状提供依据。方法:将流行病学调查采集的痰标本进行涂片和培养,对培养出的分枝杆菌进行菌型鉴定和四种一线抗结核药物敏感性测定。结果:6933人中,16例涂阳,涂阳患病率为231/10万;38例菌阳,菌阳患病率为548/10万;35株结核分枝杆菌的总耐药率为(37.1%),初始耐药率为33.3%,耐多药率为14.3%。耐不同抗结核药物的顺位由高到低依次为:H(28.6%)、S(17.1%)、R(14.3%)、E(5.7%);非结核分枝杆菌占分离菌株的24.5%。结论:我省本次流行病学调查五个点显示涂阳患病率、菌阳患病率、耐药率较高,其中菌阳患病率较我省2000年流行病学调查显著性增高(P<0.05),提示我省结核病防治形势和任务十分严峻,必须采取行之有效的措施,加强结核病的防治工作。Objective ： To analyze the results of bacteriological test and epidemiological survey of tuberculosis and to evaluate the prevalence of TB in Guizhou province. Methods ： Sputum samples were collected for smear and culture, isolates from epidemiology survey were subjected to identification and susceptibility testing against 4 anti - tuberculosis drugs. Results ：A total o5 6933 people were involved in the survey, in which 16 person were smear positive ,the prevalence of smear positive pulmonary tuberculosis is 231/100000, thirty -eight person were bacteriological positive, the prevalence of bacteriological positive pulmonary tuberculosis is 548/100000;the resistant rate to any drug is 37. 1% in 35 mycobacterium tuberculosis isolates, 33.3% in new cases, mult - drug resistence （ MDR ） wasl4.3%. The resistence rates to H, S, R, F were 28.6% , 17.1% , 14.3% , 5.7% respectively ; non - mycobacterium tuberculosis accounted for 24.5 %. Conclusion： The epidemiology survey in five points shows higher prevalence of smear positive pulmonary tuberculosis, higher prevalence of bacteriological positive pulmonary tuberculosis and higher resistence rate, especially the prevalence of bacteriological positive pulmonary tuberculosis, higher than that in 2000 significantly（P 〈0.05 ）. There is very grim situation in TB control in Guizhou province, so effective measures should be taken to strengthen the prevention of tuberculosis.

关 键 词：分枝杆菌 结核 流行病 抽样调查 

分 类 号：R52[医药卫生—内科学]