膝关节骨关节炎患者滑液中一氧化氮的动态变化及其临床意义  

Implication of dynamic changes of NO in synovial fluid of various stage OA patients

作　　者：彭丹[1] 孙材江[1] 陈游 

机构地区：[1]湖南医科大学第二附属医院,湖南长沙410011

出　　处：《现代康复》2000年第8期1192-1193,共2页Modern Rehabilitation

摘　　要：目的检测膝关节骨关节炎（ＯＡ）各期患者滑液中一氧化氮（ＮＯ）和过氧化脂质（ＬＰＯ）水平，分析并探讨其临床意义。方法选择符合诊断标准各期膝骨关节炎患者的关节滑液，用镀铜镉还原法及ＴＢＡ荧光法分别进行ＮＯ及ＬＰＯ的测定。结果骨关节炎患者各期ＮＯ含量不同，以中期最高，而ＬＰＯ在各期中有所升高，在晚期与ＮＯ出现分离现象。结论ＮＯ参加骨关节炎中软骨损害的全过程。 ＮＯ可用作判断ＯＡ中关节炎软骨损害的重要指标之一。Objective To determine the levels of nitric oxide (NO ) and lipiod peroxides (LPO) in synovial fluid (SF) of various stage OA patients and analyse the implication. Methods NO in SF of various stages of patients were determined by reduction. The LPO levels were determined by the thiobarbituric acid(TBA) reaction. Results The levels Of NO in SF of various safe OA patients was higher than that of healthy group. The levels of NO got highest at moderate stage. At last stage, the levels of LPO were gradually increasing and that of NO were decreasing. Conclusion The NO involved in the damage of articular cartilage and the levels of NO in SF could be considered one of the standards of the caritilage lesions.

关 键 词：骨关节炎 一氧化氮 氧自由基 滑液 

分 类 号：R684.302[医药卫生—骨科学]