雷公藤叶组分TZT-5对大鼠关节炎的抑制作用  

Inhibition of component TZT-5 from leaves of Tripterygium wilfordii on rheumatoid arthritis in rats

作　　者：张天齐[1] 玄玲玲[1] 姜仁涛[1] 曹淑花[1] 刘仁平[1] 李创军[2] 白金叶[1] 张东明[2] 侯琦[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所药理室,北京100050 [2]中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室,北京100050

出　　处：《中草药》2013年第12期1628-1634,共7页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81001442);高等学校博士学科点专项科研基金(20101106120023);国家科技支撑计划项目(2009BA173B03);福建省科技重大专项(2009YZ0001-1-6)

摘　　要：目的评价雷公藤叶组分TZT-5抗炎作用,尤其是对关节炎的抑制作用。方法采用巴豆油诱导的小鼠耳炎模型、角叉菜胶诱导的大鼠足肿胀模型、鸡II型胶原(CCII)诱导的大鼠关节炎模型和佐剂诱导的大鼠关节炎模型,观察TZT-5的体内抗炎活性和抗关节炎的作用。结果 TZT-5可减轻上述4个模型的炎症症状,抑制CCII和佐剂致关节炎大鼠滑膜组织炎性细胞浸润和滑膜组织增生。结论 TZT-5具有较好的抗炎作用,可明显抑制CCII和佐剂所致大鼠关节炎,具有研发成为新的抗类风湿性关节炎药物的潜力。Objective To investigate the anti-inflammatory,especially the inhibitory effects of TZT-5,an active component from the leaves of Triterygium wilfordii,on the rheumatoid arthritis of rats and to explore its pharmacodynamic effect using an arthritic model of rats.Methods The ear swelling model induced by croton oil in mice,paw edema model induced by carrageenin in rats,chicken collagen Ⅱ（CCⅡ）-induced arthritic model,and adjuvant-induced arthritic（AIA） model in rats were established,respectively.The in vivo anti-inflammatory and inhibitory effects of TZT-5 on the rheumatoid arthritis of rats were observed.Results TZT-5 could alleviate the symptoms of the above four inflammation animal models,ameliorate the infiltration of inflammatory cells in synovium,and inhibit the proliferation of synovial cells in both CCII-induced arthritic models and AIA models of rats.Conclusion TZT-5 has the ideal anti-inflammatory effects on CCII-induced arthritic model and AIA model of rats and it is a candidate as a new anti-rheumatoid arthritis drug.

关 键 词：雷公藤叶 TZT-5 抗炎 关节炎 滑膜组织 

分 类 号：R282.710.5[医药卫生—中药学]