Development of new solid phase extraction techniques in the last ten years  

几种固相萃取新技术近十年的研究进展(英文)

作　　者：范惠霞[1,2,3] 邓志鹏[1,3] 仲浩[1,3] 姚庆强[1,3] 

机构地区：[1]山东省医学科学院 药物研究所,山东济南250062 [2]济南大学山东省医学科学院医学与生命科学学院,山东济南250022 [3]山东省罕少见病重点实验室,山东济南250062

出　　处：《Journal of Chinese Pharmaceutical Sciences》2013年第4期293-302,共10页中国药学（英文版）

基　　金：supported by the Key Laboratory for Rare Disease of Shandong Province

摘　　要：Solid phase extraction （SPE） is a widely used sample pretreatment method for separation, purification and enrichment, which has been established due to its significant advantages of time-saving, low consumption of solvent, high enrichment factor, high accuracy, etc. In recent years, a variety of new SPE methods such as molecularly imprinted solid phase extraction （MISPE）, magnetic solid phase extraction （MSPE）, solid phase micro-extraction （SPME）, etc., which are superior to the conventional SPE, have been developed and been widely applied to food, drugs, and environmental monitoring. In this paper, the basic principles and methods of SPE and its new applications in different areas are reviewed.固相萃取技术是近年来发展较快并得到广泛应用的一种样品前处理方法 (分离、纯化、富集), 具有节省时间、溶剂消耗少, 富集倍数高, 准确度高等优点。随着科学技术的不断发展及研究的不断深入, 多种优于传统固相萃取技术的新型固相萃取新技术如分子印迹固相萃取、磁性固相萃取、固相微萃取等不断出现并广泛应用到食品、药品、生物及环境监测等领域。本文对几种固相萃取新技术的基本原理、方法及近十年来在不同研究领域的研究应用进行综述。

关 键 词：Solid phase extraction Molecularly imprinted solid phase extraction Magnetic solid phase extraction Solid phase micro-extraction 

分 类 号：R91[医药卫生—药学]