自体骨髓间充质干细胞移植治疗股骨头无菌性坏死的临床观察  被引量:2

Clinical Observation of Autologous Bone-marrow Mesenchymal Stem Cells in Treating Aseptic Necrosis of Head of Femur

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作  者:付强[1] 闫世杰[1] 王江泳[1] 候熙智[1] 张乐明[1] 冯建书[1] 

机构地区:[1]石家庄市第三医院骨科,河北石家庄050011

出  处:《现代生物医学进展》2013年第18期3507-3509,3563,共4页Progress in Modern Biomedicine

基  金:河北省石家庄市科技局(121461403)

摘  要:目的:观察自体骨髓间充质干细胞移植治疗股骨头无菌性坏死的临床效果及安全性。方法:对2012年9月至2013年1月期间在我院骨科住院治疗的55例患者随机分成两组,对照组接受常规治疗,治疗组接受自体骨髓间充质干细胞移植治疗治疗。结果:治疗组的临床疗效优于对照组,与对照组相比差异有统计学意义(P<0.01);治疗组治疗后的DSA检查结果与对照相比,差异有统计学意义(P<0.05);两组不良反应相互比较,无统计学意义(P>0.05)。结论:自体骨髓间充质干细胞移植治疗股骨头无菌性坏死效果显著,优于常规治疗。Objective:To explore the clinical effect of autologous bone-marrow mesenchymal stem cells in treating aseptic necrosis of head of femur.Methods:55 cases accepted treatment from Sept 2012 to Jan 2013 in our hospital were divided randomly into two groups.The control group was treated with conventional therapy and the treating group was treated with autologous bone-marrow mesenchymal stem cells.Results:The clinical effect was more remarkable in treating group than in the control group,with statistically significant difference(P0.01).The diagnosis results from the DSA showed the treating group was better than the control group and the difference was also statistically significant(P0.01).There was no statistical difference in side effects between the two groups(P0.05).Conclusion:The self bone-marrow mesenchymal stem cells had apparent clinical effect in treating aseptic necrosis of head of femur and it was superior to conventional therapy.

关 键 词:骨髓间充质干细胞 股骨头无菌性坏死 临床观察 

分 类 号:R68[医药卫生—骨科学]

 

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