多潘立酮对慢性阻塞性肺疾病机械通气患者胃肠功能障碍的临床效果观察  

Role of Domperidone in the Gastrointestinal Function of Patients with Chronic Obstructive Pulmonary Disease Treated by Mechanical Ventilation

作　　者：刘小伟[1] 高岩[1] 毕宏远[1] 翟哲[1] 卢群[2] 

机构地区：[1]哈尔滨医科大学附属第四医院重症医学科,黑龙江哈尔滨150001 [2]西安交通大学医学院附属第一医院,陕西西安710061

出　　处：《现代生物医学进展》2013年第19期3711-3713,3737,共4页Progress in Modern Biomedicine

基　　金：陕西省科技统筹创新工程计划项目(2012KTCQ03-05)

摘　　要：目的：探讨多潘立酮对慢性阻塞性肺疾病（COPD）机械通气患者胃肠功能障碍的临床效果。方法：采用前瞻性随机对照研究方法,选择2010年11月~2012年11月我院重症医学科收治的需要机械通气且存在胃肠功能障碍的COPD患者48例,按抽签法随机分为两组,对照组（n=24）为常规治疗组,治疗组（n=24）在常规治疗基础上给予鼻饲多潘立酮片10 mg,3次/天。观察周期为1周,通过观察患者胃肠功能障碍症状的恢复情况、胃排空情况及实验室检查指标评价多潘立酮的疗效。结果：治疗组和对照组胃肠功能障碍临床症状改善的有效率分别为87.5%和62.5%,治疗组显著高于对照组（P〈0.05）;治疗组和对照组胃排空功能的有效率分别为83.33%和58.33%,治疗组显著高于对照组（P〈0.05）;对照组治疗前后血红蛋白、离子、白蛋白、肌酐、尿素氮水平比较无显著差异（P〉0.05）,治疗组治疗前后各指标亦无统计学差异（P〉0.05）。治疗后两组血红蛋白,白蛋白有所升高,但各指标比较无统计学差异（P〉0.05）。结论：多潘立酮辅助治疗可以有效改善COPD机械通气患者的胃肠功能障碍,促进胃排空,提高肠内营养的耐受性。Objective： To observe the clinical efficacy of domperidone in gastrointestinal dysfunction in patients with chronic ob- structive pulmonary disease （COPD） by mechanical ventilation. Methods： A prospective randomized control study was conducted. From November 2010 to November 2012, there were 48 patients of chronic obstructive pulmonary disease with mechanical ventilation in inten- sive care unit were randomly divided into two groups. The control group （n=24） was received conventional treatment. On the basis of conventional treatment, the treatment group （n=24） was treated with domperidone tablets （10mg, 3 times per day） for one week. The re- covery of the symptom of gastrointestinal dysfunction, gastric emptying and laboratory examination were observed to evaluate the effect of domperidone. Results： The clinical symptoms of gastrointestinal dysfunction improvement rate of the treatment group and the control group were 87.5% and 62.5%, the treatment group was significantly higher than that of the control group （P〈0.05）. The gastric emptying rate of the treatment group and the control group were 83.33% and 58.33%, the treatment group was significantly higher than that in con- trol group （P〈0.05）. In control group, there were no significant differences in hemoglobin, albumin, creatinine, ion, blood urea nitrogen before and after treatment （P〉0.05）. The indexes of treatment group before and after treatment were also no statistical difference （P〉0. 05）. After treatment of two groups, hemoglobin and albumin increased, but there were no statistical differences in each index （P〉0.05）. Conclusions： Domperidone treatment can effectively improve the COPD patients with mechanical ventilation in gastrointestinal dysfimc- tion, promote gastric emptying, increase the tolerance of enteral nutrition.

关 键 词：多潘立酮 慢性阻塞性肺疾病 机械通气 胃肠功能障碍 

分 类 号：R563[医药卫生—呼吸系统]