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机构地区:[1]郑州大学第二附属医院妇产科,河南郑州450000
出 处:《中国妇幼保健》2013年第19期3153-3156,共4页Maternal and Child Health Care of China
摘 要:目的:了解黏附分子E-钙黏蛋白(E-cadherin)在子痫前期患者胎盘中的表达情况,探讨其参与子痫前期发病的机制及与胎盘重量、新生儿体重的关系。方法:以60例子痫前期(PE)妇女为研究组,其中轻度子痫前期30例(MPE组),重度子痫前期30例(SPE组)。20例正常妊娠妇女为对照组。采用免疫组化SP法检测两组胎盘组织中E-cadherin的表达水平,用平均灰度半定量表示,用SPSS软件分析其表达结果及其与胎盘重量、新生儿体重的关系。结果:E-cadherin在胎盘中的平均灰度值研究组高于对照组(P<0.01),SPE组高于MPE组(P<0.01)。研究组胎盘重量、新生儿体重低于对照组(P<0.01),SPE组胎盘重量、新生儿体重低于MPE组(P<0.01)。对照组中胎盘E-cadherin的表达与胎盘重量、新生儿体重的相关系数r分别为-0.22、-0.25,MPE组分别为-0.35、-0.44(P<0.01),SPE组分别为-0.47、-0.55(P<0.01)。E-cadherin在胎盘中的平均灰度值新生儿体重<2 500 g者高于≥2 500 g者(P<0.01)。结论:子痫前期患者胎盘中E-cadherin呈高表达,随着病情加重其表达增强,提示其可能参与到子痫前期的发病机制中,并与胎儿生长受限相关。Objective: To understand the expression of E-cadherin in placenta of patients with preeclampsia,explore the mechanism in pathogenesis of preeclampsia and its relationship with placental weight and neonatal weight.Methods: Sixty patients with preeclampsia were selected as study group,including 30 patients in mild preeclampsia subgroup and severe preeclampsia subgroup.Twenty normal pregnant women were selected as control group.Immunohistochemical SP assay was used to detect the expression levels of E-cadherin in placental tissues of the two groups with the average gray value.SPSS software was used to analyze the expression results and therelationship with placental weight and neonatal weight.Results: The average gray value of E-cadherin in study group was statistically significantly higher than that in control group(P 0.01),the average gray value of E-cadherin in severe preeclampsia subgroup was statistically significantly higher than that in mild preeclampsia subgroup(P 0.01).The placental weight and neonatal weight in study group were statistically significantly lower than those in control group(P 0.01),the placental weight and neonatal weight in severe preeclampsia subgroup were statistically significantly lower than those in mild preeclampsia subgroup(P 0.01).The correlation coefficients of E-cadherin expression with placental weight,neonatal weight were-0.22 and-0.25 in control group,-0.35 and-0.44 in mild preeclampsia subgroup(P 0.01),-0.47 and-0.55 in severe preeclampsia subgroup(P 0.01).The average gray value of E-cadherin in patients with neonatal weight 2 500 g was statistically significantly higher than that in patients with neonatal weight≥2 500 g(P 0.01).Conclusion: The expression level of E-cadherin in placental tissue of patients with preeclampsia is high,increasing with aggravation of the disease,which indicates that E-cadherin may be involved in the pathogenesis of preeclampsia,and it is correlated with fetal growth restriction.
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