化脓性脑膜炎临床特征及预后的影响因素分析  

The analysis of risk factors on clinical features and prognosis in patients with purulent meningitis

作　　者：王馥瑜 梁志娟[2] 侯晓霖[3] 王振海[3] 

机构地区：[1]宁夏体检康复中心,宁夏银川750001 [2]宁夏医科大学,宁夏银川750004 [3]宁夏医科大学总医院神经内科,宁夏银川750004

出　　处：《宁夏医学杂志》2013年第6期481-482,共2页Ningxia Medical Journal

基　　金：国家自然科学基金资助项目(81160151)

摘　　要：目的探讨化脓性脑膜炎患者临床特征与预后的相关性因素,以便及时对化患者进行治疗干预,降低其病死率、致残率及后遗症率。方法收集71例化脓性脑膜炎患者资料,对其首发症状、脑脊液实验室检查指标、治疗等因素综合分析。将脑脊液压力、白细胞计数、蛋白含量、细菌培养阳性率、耐药率等作为判断预后的指标,对患者预后情况进行分析。结果结果显示CSF细胞数>1 000个/mm3、CSF蛋白>2 g/L、CSF葡萄糖<2.8mmol/L、CSF细菌耐药率对疾病预后的影响较大。结论在影响患者预后因素的指标中,脑脊液白细胞计数、葡萄糖含量、蛋白含量、细菌耐药率均能作为预后不良的指标。Objective To investigate risk factors on clinical features and prognosis of patient with purulent meningitis,and to reduce mortality,morbidity and sequelae rate. Methods A total of 71 patients with purulent meningitis admitted in Ningxia Medical University Gener- al Hospital were retrospectively analyzed. All risk factors including disease history,clinical manifestations,complications,laboratory examinations and treatment were studied statistically and compared with two different groups. Results The cerebrospinal fluid cell count 〉 1 000/mm3 ,the cerebrospinal fluid sugar 〈2. 8 mmol/L and protein 〉2 g/L,and the cerebrospinal fluid bacteria drug resistance were significantly different be- tween two groups. Conclusion The risk factors for an adverse outcome in patients with purulent meningitis are cerebrospinal abnormal white blood cell count at admission,cerebrospinal fluid low sugar,high protein level and bacterial resistance rates.

关 键 词：化脓性脑膜炎 临床特征 预后 

分 类 号：R725.1[医药卫生—儿科]