促红细胞生成素在极低出生体重儿应用的疗效观察  

Observation of the efficacy of erythropoietin on very-low-birth-weight infants

作　　者：陈均龙[1] 卢庆晖[1] 阳红华[1] 张志刚[1] 夏晓芹[1] 

机构地区：[1]广东中山大学附属东华医院新生儿科,广东东莞523220

出　　处：《宁夏医学杂志》2013年第6期527-529,共3页Ningxia Medical Journal

摘　　要：目的探讨重组人促红细胞生成素(rHuEPO)防治极低出生体重儿早产儿贫血及早产儿脑病的疗效。方法选取57例胎龄<32周,体重<1 500 g的极低出生体重儿,分成治疗组31例,对照组26例。治疗组出生后第8 d即给rHuEP0 250 U/kg,隔日1次,共4周。并于纠正胎龄40周时做行为神经测定(NBNA评分)、脑电图(EEG)、自动脑干听觉诱发电位(AABR)及颅脑磁共振扫描(MRI)检查。结果 2组极低出生体重儿出生后血红蛋白(Hb)、红细胞压积(Hct)均逐步下降,但治疗组下降程度较对照组轻,在治疗最初2周比较差异无统计学意义(P>0.05),Hct比较有统计学意义(P<0.01),在治疗结束后Hb及Hct比较差异有统计学意义(P<0.01)。治疗组在输血例数及多次输血例数较对照组明显少(P<0.01)。治疗组纠正胎龄40周时NBNA评分得分较对照组高,2组比较有统计学意义(P<0.01)。治疗组纠正胎龄40周时EEG、AABR及颅脑MRI异常率较对照组低(P<0.01)。结论早期应用rHuEP0不仅可防治或减轻早产儿贫血程度,并可减少早产儿脑病的发生。Objective To investigate the efficacy of recombinant human erythropoietin （rHuEPO） on preventing very - low - birth -weight infants and premature infants from anemia and encephalopathy. Methods 57 infants in the neonatal ward of hospital, whose gestational age were less than 32 weeks and weight were less than 1500 grams, were randomly divided into treatment group （31 cases） and control group （26 cases）. The treatment group were given rHuEPO （250U/kg） every two days from the eighth day after birth, which lasted four weeks. The neonatal behavioral neurological assessment（ NBNA）, electroencephalogram（ EEG）, automated audi- tory brainstem response（AABR） and cranial MRI were carried when they were Corrected gestational age of 40 weeks. Results The Hb and Hct of two very - low - birth - weight infant groups both gradually declined after birth, whereas, Hb and Hct in the treatment group significantly decreased than those in control group. In the first two weeks of treatment, there was no difference in hemoglobin statistically （ P 〉 0.05 ）, but there were statistically significant differences in Hct （ P 〈 O. 01 ）. After the treatment, there were significant differences in both Hb and Hct in statistics （P 〈0.01 ）. Treatment group cases in blood transfusion and blood transfusion cases many times less than the control group obviously, contrast in the two groups were statistically significant differences （P 〈 0.01 ）. Treatment group correc- ted gestational age of 40 weeks NBNA score was higher than it in the control group,, two groups of contrast were statistically significant differences（ P 〈 0.01 ）. Treatment group corrected gestational age of 40 weeks electroencephalography （EEG） and brainstem auditory e- voked potential （AABR） and craniocerebral MRI abnormality rates were lower than those in control group, two groups of contrast were statistically different（P 〈 0.01 ）. Conclusion Early application of rHuEPO could not only prevent premature anemia or

关 键 词：极低出生体重 促红细胞生成素 贫血 早产 早产儿脑病 

分 类 号：R722.6[医药卫生—儿科]