慢性心力衰竭患者血清线粒体偶联因子-6含量变化及意义  

The Changes of Mitochondrial Coupling Factor 6 Levels in Patients with Chronic Heart Failure and the Significance

作　　者：刘涌[1] 陈峰[1] 庞继恩[1] 刘志涛[1] 甄玉改[1] 崔静[1] 

机构地区：[1]解放军401医院心内科,山东青岛硕士研究生266071

出　　处：《西南军医》2013年第4期366-368,共3页Journal of Military Surgeon in Southwest China

摘　　要：目的研究慢性心力衰竭(CHF)患者血清线粒体偶联因子-6(CF6)含量变化及意义。方法分别测定60例CHF患者与30例健康对照患者血清CF6及脑钠肽(BNP)浓度,并对检测结果进行对比分析。结果CHF患者血清CF6、BNP浓度较对照组有统计学意义(P<0.01),且随心力衰竭程度的加重而升高,CHF各组间差异有统计学意义(P<0.01)。结论血清CF6在心力衰竭的发生发展过程中有一定的病理生理意义。Objective To study the changes of mitochondrial coupling factor 6 （CF6） levels in patients with chronic heart failure （CHF） and the significance. Methods The concentrations of CF6 and brain natriuretic peptide （BNP） in 60 patients with CHF and those of 30 healthy controllers were measured respectively. Results The concentrations of CF6 and BNP in patients with CHF were higher than those in controllers, the difference was of statistical significance （P〈0.01）, and kept raising up with aggravation of heart failure; the difference between each CHF group was of statistical significance （P〈0.01）. Conclusions CF6 is of certain pathophysiological effect in the occurrence and progression of heart failure.

关 键 词：慢性心力衰竭 线粒体偶联因子-6 脑钠肽 

分 类 号：R541[医药卫生—心血管疾病]