左氧氟沙星聚乙烯醇微粒的制备及其特性研究  

Preparation of Levofloxacin Polyvinyl Alcohol Micro-Particles and Study on Its Characteristics

作　　者：黄伟锋[1] 曾斌[1] 郭彬[1] 

机构地区：[1]广州中医药大学附属深圳市中医院药学部,广东深圳518033

出　　处：《中国药业》2013年第13期36-38,共3页China Pharmaceuticals

摘　　要：目的制备左氧氟沙星聚乙烯醇微粒并研究其特性。方法以聚乙烯醇Mγ31 000～50 000为载体,OPDT-8喷雾干燥床制备左氧氟沙星聚乙烯醇微粒,观察制剂的形态、载药量、包封率和体外溶出度。结果所制左氧氟沙星聚乙烯醇微粒为近球形、表面有孔,平均粒径为16.55μm,载药量为32.96%,包封率为96.06%,50 min时体外累积溶出百分率达90%以上。结论该制剂制备工艺可行,质控方法简单,制剂符合左氧氟沙星的用药要求。Objective To prepare Levofloxacin Polyvinyl Alcohol Micro-Particles（LFX-PVA-MP）and to study its characteristics.Methods LFX-PVA-MP was prepared by OPDT-8 spray drying process with PVA Mγ31 000-50 000 as carrier.Its morphology,drug-loading capacity,encapsulation rate and in vitro dissolution were studied and observed.Results The prepared LFX-PVA-MP was near spherical form with porous surface and the average particle size of 16.55 μm.The drug-loading capacity was 32.96%,the encapsulation rate was 96.06%and the in vitro cumulative dissolution percentage reached over 90%within 50 min.Conclusion This preparation technology is feasible and the quality control method is simple.The preparation conforms to the medication demand of levofloxacin.

关 键 词：左氧氟沙星 聚乙烯醇 微粒 喷雾干燥法 特异性 

分 类 号：R945[医药卫生—微生物与生化药学] R978.69[医药卫生—药剂学]