复方倍他米松联合低浓度5-氟尿嘧啶治疗瘢痕疙瘩的疗效观察  

Clinical research on combination therapy of compound betamethasone and low concentration 5-fluorouracil in the treatment of keloid

作　　者：刘丽华[1] 何云飞[1] 杨万军[1] 周薇[1] 

机构地区：[1]四川省攀枝花市中心医院皮肤科,617067

出　　处：《重庆医学》2013年第20期2364-2365,共2页Chongqing medicine

摘　　要：目的探讨低浓度5-氟尿嘧啶(5-FU)与复方倍他米松混合注射治疗瘢痕疙瘩的疗效。方法将该院87例患者分成A、B、C 3组。对A组(n=30)患者行单纯低浓度5-FU注射,对B组(n=29)患者行单纯复方倍他米松注射,对C组(n=28)患者行低浓度5-FU与复方倍他米松的混合液注射,3组患者均每隔3周注射1次,共4次。分别于治疗后第1、3、12个月进行随访。结果共有81例患者按要求完成疗程,在第12个月随访时,A、B、C组的有效率分别为32.0%、58.6%、70.4%,C组患者有效率明显高于A、B组。结论低浓度5-FU与复方倍他米松联合治疗瘢痕疙瘩,安全有效。Objective To examine the therapeutic efficacy of intralesional injection of compound betamethasone combined with low concentration 5-fluorouracil. Methods 87 patients were divided into group A,B and C. 30 patients in group A were treated with intralesional injection of 5-fluorouracil. 29 patients in group B received treatment of compound betamethasone. 28 patients in group C were treated with a mixture of compound hetamethasone and low concentration 5-fluorouracil. Three groups of patients were in- jected once every three week,with a total of four times. All the patients were observed respectively on month 1,3 and 12 after the start of treatment. Results A total of 81 patients completed treatment according to the requirement. In the 12-month follow-up,the efficiency of group A,B and C were 32.0% ,58.6% and 70.4% ,respectively. The efficiency of group C was obviously higher than that of group A and B. Conclusion The combination therapy for keloid is safe and effective by using compound betamethasone and low concentration 5-fluorouracil.

关 键 词：瘢痕疙瘩 复方倍他米松 5-氟尿嘧啶 

分 类 号：R622[医药卫生—整形外科]