2008～2010年重庆市某院临床分离病原菌及耐药情况分析  

Distribution and antibiotic resistance of clinical isolates of pathogenic bacteria in a hospital of Chongqing from 2008 to 2010

作　　者：刘少华 刘琪[1] 

机构地区：[1]重庆市涪陵中心医院检验科,408000

出　　处：《重庆医学》2013年第20期2384-2386,共3页Chongqing medicine

摘　　要：目的分析2008～2010年重庆市某院临床分离病原菌分布及其耐药情况。方法收集该院临床送检标本8 921份,采用Micro Scan A/s-4系统进行细菌鉴定和药敏试验。结果细菌培养阳性3 822份,阳性率为42.84%,经统计,临床分离菌处于前5名的是:铜绿假单胞菌(677例)、鲍曼/溶血不动杆菌(648例)、大肠埃希菌(494例)、肺炎克雷伯菌(491例)、金黄色葡萄球菌(215例);对大多数药物耐药率较高的有鲍曼/溶血不动杆菌、肺炎克雷伯菌、大肠埃希菌以及金黄色葡萄球菌,铜绿假单胞菌对各种药物的敏感性平均为45%;另外鲍曼/溶血不动杆菌的检出率上升很快,有超过铜绿假单胞菌的趋势。结论建立该院细菌耐药数据库,为临床上合理应用抗菌药物具有重大意义。Objective To investigate the distribution and antibiotic resistance of clinical isolates of pathogenic bacteria in a hos- pital of Chongqing from 2008 to 2010. Methods 8 921 samples were collected from a hospital of Chongqing. Identification of bacteria and susceptibility tests were performed by using MicroScan A/s-4 system. Results A total of 3 822 clinical samples were analyzed,and 42.84 % of these were bacteria-positive. According to statistical analysis, the clinical isolates in the top five were Pseudo- monas aeruginosa （677 cases）, Baumann/hemolysis Acinetobacter （648 cases）, Klebsiella pneumonia （494 cases）, Escherichia coli strains （491 cases）, and Staphylococcus aureus （215 cases）. And the results revealed that antibiotic resistance of the five pathogens to most antimicrobial increased year by year. The resistance of Baumann/hemolysis Acinetobacter, Klebsiella pneumonia, Escherichi- a coli and Staphylococcus aureus to antimicrobial agents were higher than others, and the antibiotic sensitivity in Pseudomonas aeruginosa was about 45 %. In addition, the positive rate of Baumann/hemolysis Acinetobacter increased fast in three years. Conclu- sion Periodically bacterial resistance surveillance and bacterial resistance database establishment are of great importance for clini- cally rational application of antibiotic.

关 键 词：细菌 耐药 抗菌药物 药敏实验 

分 类 号：R446.5[医药卫生—诊断学]