2009年甲型流感过后散发成人流感样病例病原学特征  

Virus spectrum features of adult influenza-like fever in outpatients

作　　者：杨晓花[1] 陈美芳[1] 高燕[1] 郗盟[1] 杨霞[1] 郭晓琳[1] 孙春玲[1] 朱建莹[1] 谢艳迪[1] 刘雅芬[1] 魏来[1] 

机构地区：[1]北京大学人民医院肝病研究所感染科,100044

出　　处：《中华医学杂志》2013年第25期1962-1964,共3页National Medical Journal of China

摘　　要：目的 分析2010年6月-2012年2月的流感样病例（ILI）病原学资料,探讨成人散发ILI病原谱特征.方法 采集502例ILI患者的咽拭子标本.279例用多重PCR检测12种呼吸道病毒；413例用细胞培养法分离鉴定流感病毒,进行统计分析.结果 多重PCR法中26.9％ （75/279）病例检出呼吸道病毒,甲型流感病毒（FLU-A）是2010-2011年流行优势株,占病毒阳性病例85.3％,占ILI的22.9％（64/279）.其他呼吸道病毒阳性率低于3％.413例细胞培养分离的ILI中,新甲型H1N1（pH1N1）阳性率2.7％（11/413）,H3阳性率2.4％（10/413）,乙型流感病毒（FLU-B）阳性率6.5％ （27/413）.2010-2011年优势株为FLU-A,2011-2012年优势株为FLU-B.2009-2012年流感流行高峰分别出现在2009年11月、2011年1月和2012年1～2月,2010和2011年的ILI％整体低于2009年同期水平.结论 pH1N1对流感季节性无影响.甲流过后散发ILI的病原以流感病毒为主.高峰在次年1～2月份.Objective To analyze the results of detection on respiratory virus of influenza-like illness （ILI） in Beijing from June 2010 to February 2012 and understand the virus spectrum of adult influenza-like fever.Methods A total of 502 swabs were collected and 279 throat swabs tested for 12 respiratory viruses with multiplex reverse transcription-polymerase chain reaction （RT-PCR）.And 413 swabs were tested for pH1N1 by virus isolation influenza viruses.And the data were statistically analyzed.Results One or two viruses were detected in 26.9% （75/279） of the samples.Influenza A virus （FLUA） accounted for 85.3% of positive samples and 22.9% （64/279） of ILI tested.The positive rate of other viruses was less than 3.0 %.The positive rates among the following subtypes were：2.7% （11/413） for pH1N1,2.4% （10/413） for H3 and 6.5% （27/413） for FLU-B.FLU-A was the predominant virus during the 2010-2011 influenza season and the positive rate peaked in January 2011 in Beijing and north China.FLU-B was the primary virus during the 2011-2012 influenza season and the positive rate peaked in January and February 2012.There was a significant reduction in the incidence of ILI in 2010 and 2011 when compared with 2009.During the 2009-2012 influenza seasons,the incidence peaked in December 2009,January 2011 and January and February 2012 in Beijing.Conclusion Exposure to pH1N1 had no impact on typical influenza seasonal peaks.Influenza virus was the predominant virus of adult influenza-like fever cases after the pandemic period of influenza A （H1N1） 2009 and the positive rate peaked in January and February during the 2009-2012 influenza seasons.

关 键 词：流感病毒A型 流感病毒B型 病原学 

分 类 号：R511.7[医药卫生—内科学]