慢性阻塞性肺疾病急性加重期肺栓塞发生率的荟萃分析  

Incidence of pulmonary embolism in patients with acute exacerbations of chronic obstructivepulmonary disease： a meta-analysis

作　　者：王芳[1] 程兆忠[1] 王镜銮[1] 韩伟忠[1] 孙妮娜[1] 

机构地区：[1]青岛大学医学院附属医院东区呼吸内科,266101

出　　处：《中华医学杂志》2013年第24期1868-1871,共4页National Medical Journal of China

摘　　要：目的评价慢性阻塞性肺疾病（COPD）急性加重期患者肺栓塞的发生率。方法全面检索截至2012年6月的PubMed数据库（1966年一）、Embase数据库（1974年～）、中国生物医学文献数据库（1978年一）、中国期刊全文数据库（1979年～）及维普数据库（1989年一），查找研究COPD急性加重期肺栓塞发生率的文献，采用stata11．0版统计软件进行荟萃分析。结果在检索到的2273篇文献中，共有5篇文献符合纳入标准（4篇英文文献，1篇中文文献）。共纳入762例患者，其中肺栓塞145例。报道的COPD急性加重期肺栓塞发生率为3．3％～33．0％，荟萃分析合并发生率为15．8％（95％CI为5．1％一26．4％），在不明原因的COPD急性加重患者中，肺栓塞发生率为29．O％（95％CI为20．8％一37．1％）。结论COPD急性加重期尤其是不明原因者肺栓塞发生率较高，应予以重视。Objective To evaluate the incidence of pulmonary embolism in patients with acute exacerbations of chronic obstructive pulmonary disease （COPD）. Methods Comprehensive searches as of June 2012 were performed in PubMed （1966-）, Embase （1974-）, Chinese Biomedical Literature Database （1978-）, Chinese Journal Full-text Database （1979-） and VIP Database （1989-） for literatures on the incidence of pulmonary embolism in patients with acute exacerbations of COPD. Meta- analysis was conducted with Stata version 11.0. Results Among 2273 articles identified, 5 studies met the inclusion criteria （4 in English, 1 in Chinese）. The total sample size was 762 patients, among whom 145 were diagnosed with pulmonary embolism. The incidence of pulmonary embolism ranged from 3.3% to 33.0%. Meta-analysis showed that the combined incidence was 15.8% （95% CI： 5. 1% -26. 4% ）. Among patients with acute exacerbations of COPD of unknown etiology, the incidence was 29. 0% （95% CI： 20. 8% -37. 1% ）. Conclusions There is a high incidence of pulmonary embolism in patients with acute exacerbations of COPD, especially among those of an unknown etiology. More attention should be paid to this population.

关 键 词：肺栓塞 肺疾病 慢性阻塞性 发病率 META分析 

分 类 号：R563.9[医药卫生—呼吸系统]