心血管危险因素与认知功能的相关性  

Correlation of cardiovascular risk factors and cognitive function

作　　者：王晓楠[1] 白小涓[1] 刘静[1] 韩露露[1] 陈香美[2] 

机构地区：[1]中国医科大学附属第一医院老年病科,沈阳110001 [2]解放军总医院肾内科

出　　处：《中华医学杂志》2013年第26期2048-2051,共4页National Medical Journal of China

基　　金：国家重点基础研究发展计划（G2007CB507405）

摘　　要：目的评价心血管危险因素及其严重程度与认知功能的相关性。方法以沈阳社区为基础的横断面研究，利用Framingham危险评分方程评价505名健康研究对象的心血管危险因素，计算Framinghgin危险评分积分值，估测未来10年冠心病的发生风险，并根据发生风险的大小将研究对象分为低危组（10年冠心病发生风险〈10％），中危组（10％～20％）和高危组（10年冠心病发生风险〉20％）；并根据年龄将研究对象分为5组：≤44岁组，45—54岁组，55～64岁组，65～74岁组和≥75岁组。用画钟测验及简易精神状态量表（MMSE评分）评估认知功能，比较不同危险分组间的认知功能水平，计算Framingharn危险评分积分值与认知功能的相关性。结果低危组的Framiugham危险评分积分值，画钟测验得分及MMSE评分分别为（2．6±0．8）、（4±1）及（27±3）分；与低危组相比较，中危组的Framingham危险评分积分值显著高、MMSE评分显著低[（8．0±2．0）及（25±4）分，均P〈0．01]，高危组的Framingham危险评分积分值显著高（均P〈0．01），画钟测验得分及MMSE评分均显著低[（9．7±1．0）、（3±1）、（23±4）分，均P〈0．01]；与中危组相比较，高危组的画钟测验得分及MMSE评分均显著低（均P〈0．05）；Framingham危险评分积分值与认知功能（画钟测验得分及MMSE评分）呈负相关，相关系数分别为-0．196（P〈0．01）及-0．333（P〈0．01）。结论健康人群心血管因素与认知功能存在负相关，危险因素的项目越多，程度越重，Framingham危险评分积分值越高，认知功能水平越低。Objective To evaluate the relationship between cardiovascular risk factors and cognitive function in a healthy population. Methods A community-based cross-sectional study was conducted in Shenyang. The Framingham gender-specific risk equation was employed to evaluate the cardiovascular risk factors, calculate Framingham risk score and estimate the risk of lO-year coronary heart disease （CHD）. A total of 505 study subjects were divided into 3 groups according to 10-year CHD risk： low risk（ 〈 10% ）, moderate risk（ 10% -20% ） and high risk groups（ 〉 20% ）. They were also divided into 5 groups according to age; ≤44 year old; 45 -54 year old; 55 -64 year old; 65 -74 year old and ≥75 years old. Clock drawing test and mini-mental state examination （MMSE） were used to evaluate the cognitive function and compare it among different risk groups. And correlation coefficients between Framingham risk score and cognitive function were calculated. Results Framingham risk score,clock drawing test sore and MMSE score in the low risk group was （2.6 ± 0. 8）, （4 ± 1 ） and（27 ± 3 ）. In comparison to low risk group, Framingham risk score increased significantly（P 〈 0. 01 ）, MMSE score（25 ± 4） decreased significantly（ P 〈 0. 01 ） in moderate risk group, Framingham risk score （9.7 ± 1. 0） increased significantly （ P 〈 0. 05 ） and clock drawing test scores （3 ± 1 ） and MMSE scores （23 ± 4） decreased significantly （P 〈 0. 05 ） in high risk group; in comparison to moderate risk group, clock drawing test and MMSE scores decreased significantly （P 〈0. 05） in high risk group. There was a significantly inverse correlation between Framingham risk score and cognitive function. And the Pearson correlation coefficients were -0. 196（ clock drawing test, P 〈0. 01 ） and - 0. 333 （ MMSE, P 〈 0. 01 ）. Conclusions An inverse correlation exists between cardiovascular risk factors and cognitive function in healthy population. With more risk factors a

关 键 词：认知 心血管疾病 危险因素 

分 类 号：R54[医药卫生—心血管疾病]