不同出生体质量儿0～6月龄体格生长前瞻性队列研究  

Prospective cohort study of physique growth of infants born with different weights aged 0-6 months

作　　者：薛海莉[1] 赵勇[1] 且亚玲[1] 韩令力[1] 程茜[2] 张站站[2] 王念蓉[3] 李廷玉[4] 

机构地区：[1]重庆医科大学公共卫生与管理学院营养与食品卫生教研室.重庆400016 [2]重庆医科大学附属儿童医院儿保科.重庆400014 [3]重庆市妇幼保健院儿保科,重庆400010 [4]重庆市儿科医学研究所儿童营养研究中心,儿童发育疾病研究省部共建教育部重点实验室,重庆400014

出　　处：《重庆医科大学学报》2013年第8期817-822,共6页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:30901189);重庆市教委首届高等学校青年骨干教师资助计划项目(编号:渝教人【2011】32号)

摘　　要：目的：了解不同出生体质量儿在生后6个月内的体格生长情况,分析体质量对后续体格生长的影响。方法：于2010年4月至2012年1月,在重庆2所大型医院儿保科招募和随访前瞻性队列人数共341人,其中巨大儿（macrosomia,M）组145人,正常出生体质量儿（normal birth weight,NBW）组196人。每月随访1次至6月龄,进行出生问卷调查和体格检查。结果：M组生后6个月内的超重率分别为5.8%、7.0%、4.7%、8.1%、12.8%、7.0%;NBW组生后6个月内的超重率分别为1.4%、1.4%、5.0%、5.0%、4.2%、8.4%;两组生后6个月内均出现超重情况且5月龄时M组的超重率与NBW组相比差异有统计学意义（χ2=5.695,P=0.034）;M组中,生后1个月内男婴体质量的生长速度大于女婴（t=2.327,P=0.022）,在4~5月间体质量的生长速度女婴大于男婴（t=-2.216,P=0.029）。M组在生后3个月内体质量的生长速度低于NBW组（t=-6.883,P=0.000）。M组身长的生长速度与NBW组无明显差异。婴儿出生体质量与6月龄身长的体质量Z评分均成正相关（P〈0.05）。结论：M组生后6个月内生长水平高于NBW组,但是体质量的生长速度在出生后3个月内M组低于NBW组,出现减速生长的趋势。性别差异仅在M组中存在,M组在5月龄超重检出率最高。出生体质量与婴儿6月龄身长的体质量Z评分成正相关。Objective ：To investigate the physique growth of infants born with different weights within 6 months after birth. Methods： Totally 34＇1 infants were recruited in this cohort study from the department of child health care in two hospitals in Chongqing from April 2010 to January 2012,including 145 macrosomia（M） and 196 normal birth weight（NBW） infants. Follow-up visit was carried out monthly with questionnaire and physique examination until the infants reaching the 6th month. Results： Overweight incidences of M infants aged 0-6 months were 5.8%,7.0%,4.7%,8.1%, 12.8%,7.0% while those of NBW infants were respectively 1.4%, 1.4%,5.0%, 5.0%,4.2%,8.4%. Overweight occurred in both groups and significant differences were observed between M group and NBW group at the 5th month（x2=5.695,P=O.034）. In M group,weight growth velocity of baby boy was faster than that of baby girl at 1-month-oldNBW infants（t=-6.883,P=0.000）. There was no difference in growth of body length between two groups. The correlation anal- ysis demonstrated that weight-for-length Z score at 6-month-old was positively correlated with birth weight（P〈O.05）. Conclusions：Development is faster in M infants than in NBW infants at 0-6 month, however, weight growth velocity is slower in M infants than in NBW infants at the first 3 months. Overweight incidence of 5- month-old M infants is the highest. Correlation is observed between birth weight and weight-for-length Z score at 6-month-old.

关 键 词：巨大儿 生长水平 生长速度 减速生长 

分 类 号：R179[医药卫生—妇幼卫生保健]