三种方案对散发型白癜风CD4^+/CD8^+T细胞比值及CD4^+CD25^+ Treg的影响  

Effect on CD4^+/CD8^+T Lymphocyte Ratio and CD4^+CD25^+ Treg of Three Treatments to Patients with Sporadic Vitiligo

作　　者：叶蓉[1] 黄星涛[1] 聂李平[1] 胡小平[1] 江晓君[1] 

机构地区：[1]北京大学深圳医院,广东深圳518036

出　　处：《皮肤性病诊疗学杂志》2013年第3期147-149,共3页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：深圳市科技计划项目(编号:201102013)

摘　　要：目的:检测三组散发型白癜风患者治疗前后外周血CD4+/CD8+T细胞比值及CD4+CD25+调节性T细胞水平,评价三种治疗方案对散发型白癜风免疫功能的影响。方法:将76例患者随机分为三组:治疗①组:单用吡美莫司治疗;治疗②组:吡美莫司联合中药方剂治疗;治疗③组:吡美莫司联合白芍总苷治疗,用流式细胞仪对三组患者治疗前后外周血CD4+/CD8+T细胞比值及CD4+CD25+调节性T细胞水平进行检测。结果:与治疗前相比,治疗后三组散发型白癜风患者外周血中CD4+/CD8+T细胞比值和CD4+CD25+调节性T细胞水平均升高,差异均有统计学意义(P值均<0.05)。吡美莫司联合白芍总苷组变化水平高于单用吡美莫司组,但低于联合中药方剂组,差异均有统计学意义(P<0.05)。结论:三种方案均能不同程度的提高散发型白癜风患者外周血CD4+/CD8+T细胞比值及CD4+CD25+调节性T细胞水平。Objective： To detect the CD4＋/CD8＋ T lymphocyte ratio and the CD4＋ CD25＋ Treg level in peripheral blood of patients with sporadic vitiligo, and to investigate the effect on im- mune system by the three treatments. Methods：76 patients with sporadic vitiligo were randomly divided into three groups： patients in group 1 were treated by pimecrolimus, patients in group 2 were treated by pimecrolimus and Chinese proprietary, patients in group 3 were treated by pimecrolimus and TGP. The CD4＋/CD8＋ T lymphocyte ratio and the CD4＋ CD25＋ Treg level in patients of the three groups, before and after treatment, were detected by flow cytometry. Results ： In each group, the CD4＋/CD8＋ T lymphocyte ratio and the CD4＋ CD25＋ Treg level increased af- ter treatment（P 〈0. 05 ）. The CD4＋/CD8＋ T lymphocyte ratio and the CD4＋ CD25＋ Treg level in group 3 was higher than that in the group 1 which treated by pimecrolimus, but lower than in group 2 （P 〈 0. 05 ）. The difference showed statistical significance. Conclusion： All three treat- ments could improve the level of CD4＋/CD8＋ T lymphocyte ratio and the CD4＋ CD25＋ Treg level in patients with sporadic vitiligo.

关 键 词：散发型白癜风 白芍总苷 吡美莫司 CD4+ CD8+T细胞比值 CD4+CD25+调节性 T细胞 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]