归芍地黄汤联合PDT治疗肝肾不足型ESMD的疗效观察  

Effect of Guishao Dihuang Decoction combined with photodynamic therapy for exudative senile macular degeneration with snydrome of liver and kidney deficiency

作　　者：刘安[1] 任秉仪[1] 徐朝阳[1] 金威尔[1] 陈梅珠[2] 曹明芳[1] 江蕊[1] 刘宏真[3] 张婧文[1] 

机构地区：[1]福建中医药大学附属人民医院眼科,福州350004 [2]南京军区福州总医院 [3]福建中医药大学

出　　处：《中国中医眼科杂志》2013年第3期161-164,共4页China Journal of Chinese Ophthalmology

基　　金：福建省卫生厅重点课题资助项目(wzzyb0901;zlcyk01)

摘　　要：目的观察归芍地黄汤联合PDT治疗肝肾不足型渗出型年龄相关性黄斑变性(ESMD)的疗效。方法将肝肾不足型ESMD患者67例95只眼,半随机分3组:PDT治疗组,中药治疗组和联合治疗组并给予相应的治疗,观察其疗效。结果 (1)在视力改善及眼底出血渗出吸收方面,治疗1个月时中药联合PDT组及中药组均优于单纯PDT组(P<0.05),而治疗3个月时中药联合PDT组优于PDT组及中药组(P<0.05)。(2)治疗3个月后在黄斑水肿消退、CNV闭合、临床总体疗效及复发率方面,中药联合PDT组优于PDT组(P<0.05)及中药组(P<0.01);PDT组优于中药组(P<0.05)。结论归芍地黄汤、PDT治疗ESMD黄斑下CNV均有一定的临床疗效,但以二者的联合治疗效果更佳。OBJECTIVE To evaluate the effect of Guishao Dihuang Decoction combined with photodynamic therapy （PDT） for exudative senile macular degeneration （ESMD） with snydrome of liver and kidney deficiency. METHODS Sixty seven cases （95 eyes） for ESMD with snydrome of liver and kidney deficiency were randomly divided into PDT treatment goup （PTG）, Chinese medicine treatment group （CMTG）, and combined treatment group （CTG）. Clinical effects were investigated after respectively corresponding treatment. RESULTS The effect of CTG and CMTG was better than that of PTG after 1 month therapy. It showed significant difference in the 3 groups on improving visual acuity, absorbing haemorrhage and exudation, fading macular edema and CNV, and recurrence rate. CTG got a better effect than CMTG and PTG （P〈0.05）, and PTG got a better effect than CMTG （P〈0.05）. CONCLUSIONS The therapeutic efficacy of Guishao Dihuang Decoction and PDT for CNV beneath macular was positive. and combination of the two therapy was more effective.

关 键 词：年龄相关性黄斑变性 归芍地黄汤 光动力治疗 脉络膜新生血管 

分 类 号：R276.7[医药卫生—中医五官科学] R774.5[医药卫生—中医学]