Pre-S1、S2抗原检测在乙型肝炎临床诊断中的作用及价值  

Clinical diagnosis value and function of combined detection of Pre-S1 and Pre-S2 antigen in patients with hepatitis B

作　　者：李青峰 毕雷 尚鹏程 汪波 简玲 

机构地区：[1]成都市公共卫生临床医疗中心,四川成都610066

出　　处：《中国医药科学》2013年第14期119-120,共2页China Medicine And Pharmacy

摘　　要：目的探讨Pre-S1、S2抗原检测在乙型肝炎临床诊断中的作用及价值。方法回顾性分析2010年6月～2012年6月笔者所在医院就诊的Pre-S1、Pre-S2抗原检测为阳性和两项检测结果均为阳性的患者各50例临床资料,根据检查方法分为Pre-S1组、Pre-S2组与观察组。所有患者均进行HBV-DNA含量检测,>1.0×103copiese/mL即为阳性,比较三组患者HBV-DNA检出率。结果观察组HBV-DNA检出率为94.0%,明显高于Pre-S1组(86.0%)与Pre-S2组(80.0%),差异具有统计学意义(P<0.05)。结论临床上检测Pre-S1、S2抗原的含量可以为乙肝病毒的复制提供可靠地依据,如果在同一个样本中检测出Pre-S1、S2两种抗原,则可以说明乙肝病毒已经复制。Objective To study the Clinical diagnosis value and function of combined detection of Pre-S1 and Pre-S2 antigen in patients with hepatitis B. Methods The clinical data of Pre-S1 positive 50 patients, Pre-S2 positive 50 patients and two antigens positive 50 patients in our hospital from June 2010 to June 2012 were chosen and retrospectively analyzed. All patients were divided into the Pre-S1 group （50 cases）, Pre-S2 group（50 cases） and experiment group （50 cases） according to the detection method. All the patients were given HBV-DNA content detection,of which more than 1 ×103 copiese/mL was positive.The HBV-DNA detection rates of three groups were compared. Results The HBV-DNA detection rate of experiment group was 94%, significantly higher than that of Pre-S1 group 86.0% and Pre-S2 group 80.0%.The differences were statistically significant（P 〈 0.05）. Conclusion Determination of Pre-S1, S2 antigen can provide reliable basis for HBV-DNA replication in the clinical,If Pre-S1 and S2 antigen is detected in the same sample,that can explain the hepatitis B virus has been copied.

关 键 词：乙型肝炎病毒 PRE-S1抗原 Pre—S2抗原 复制 

分 类 号：R512.6[医药卫生—内科学]