膜缓控释给药系统促进损伤组织的修复  

A membrane controlled release drug delivery system promotes injured tissue repair

作　　者：李伟[1] 戴江华[2] 罗军[2] 戴闽[3] 高乾坤[1] 

机构地区：[1]南昌大学研究生院医学部,江西省南昌市330006 [2]南昌大学第二附属医院,南昌大学骨与神经再生康复研究中心,江西省南昌市330006 [3]南昌大学第一附属医院,江西省南昌市330006

出　　处：《中国组织工程研究》2013年第25期4699-4706,共8页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金资助项目(81160184);江西省自然科学基金资助项目项目(20114BAB205044)~~

摘　　要：背景:目前研究多注重缓控释给药膜的缓控释效果及其生物相容性,也有开展缓控释给药膜参与损伤组织修复的机制研究,其中干细胞是损伤组织修复的关键因素,但干细胞与缓控释给药膜之间的联系尚未得到足够关注。目的:分析膜缓控释给药系统在组织损伤修复中的研究现状与进展。方法:以"缓释系统,膜,药物载体,组织损伤修复,干细胞归巢;sustained-release system,membrane,drug delivery,injuries and repairs of tissue,stem cell homing"为关键词,采用计算机检索Pubmed数据库、中国知网、Elsevier数据库1992年1月至2012年12月有关膜缓控释给药系统临床应用及实验研究的文章。结果与结论:在膜缓控释给药系统中高分子材料几乎成了药物和生长因子在传递、渗透过程中不可分割的组成部分。虽然药物缓释系统的发展与制膜技术都在不断的更新,但距离完全达到理想的应用标准还有一定的差距,如不具备主动吸引干细胞定向迁移与分布的生物学功能。近年来膜缓控释给药系统出现新的发展方向,即不仅能起到诱导干细胞定向分化的作用,也能诱导干细胞向损伤部位定向分布,从而促进损伤组织再生修复。BACKGROUND： At present many studies have pay attention to the sustained-release and controlled-release effects, as well as biocompatibiUty, in membrane controlled release drug delivery system. There are also some studies addressing the mechanisms underlying injured tissue repair with these drug membranes, in which stem cells are the key factors. However, the association between stem cells and the sustained and controlled drug release membrane has not yet been paid enough attention. OBJECTIVE： To analyze the current research status and progress of membrane sustained-release system in the repair of tissue injuries. METHODS： Using the keywords of ＂sustained-release system, membrane,drug delivery, injuries and repairs of tissue, stem cell homing＂ in Chinese and English, a computer search of PubMed, CNKI＇, Elsevier databases was performed for articles published from January 1992 to March 2012. Articles related to clinical application and experiment research of sustained-release and controlled-release pharmaceutical polymer materials were included. RESULTS AND CONCLUSION： In the membrane sustained-release system, polymer materials have almost become the critical part of drugs and growth factors in the process of infiltration and penetration. Although drug delivery system and membrane preparation technology are constantly updated, it is not enough to achieve the desired application standards, such as do not have the initiative to attract direct migration and distribution of stem cells. In recent years, there is a new development trend for membrane sustained-release system, which not only can induce stem cells homing to injury sites, but also can promote the differentiation and distribution of stem cells, thereby promoting the renovation of tissue injury.

关 键 词：生物材料 生物材料综述 膜缓控释给药系统 缓释系统 膜 药物载体 组织损伤修复 干细胞归巢 综述 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]