聚甲基丙烯酸甲酯骨水泥充填治疗骨损伤后的肺功能变化  

Changes of pulmonary function after bone injury treated with polymethylme-thacrylic bone cement

作　　者：关继奎[1] 赵丽[1] 姜屿[1] 李泽宝[1] 巢鹏程[1] 魏敏杰[1] 王慧[1] 刘建国[2] 

机构地区：[1]大庆油田总医院骨科,黑龙江省大庆市163001 [2]吉林大学第一医院骨科,吉林省长春市130021

出　　处：《中国组织工程研究》2013年第25期4727-4732,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:目前聚甲基丙烯酸甲酯骨水泥充填在治疗骨折以及人工关节置换骨损伤中的应用已很普遍,对于其引起的肺功能变化,尤其是老年骨损伤患者,应积极防治。目的:观察骨损伤应用聚甲基丙烯酸甲酯骨水泥充填治疗后患者的肺功能变化。方法:选取2010年5月至2011年6月大庆油田总医院骨科收治的骨折以及人工关节置换骨损伤患者24例,应用聚甲基丙烯酸甲酯骨水泥充填治疗,比较治疗后1d以及1周的肺活量、用力肺活量、最大通气量变化。结果与结论:所有应用聚甲基丙烯酸甲酯骨水泥治疗骨折以及人工关节置换的骨损伤患者,在治疗后1d的肺活量(2.45±0.56)L、用力肺活量(2.20±0.39)L、最大通气量(50.9±23.9)L,均明显低于治疗后1周。说明应用聚甲基丙烯酸甲酯骨水泥可以在一定程度上影响患者的肺功能,这种改变可能与骨水泥的使用导致肺组织的微血管栓塞有关,需要加强监测以及通过在治疗前后应用药物来预防和治疗肺栓塞。BACKGROUND： At present, the polymethylme-thacrylic bone cement filling has been widely used in the treatment of fractures and bone injuries during arthroplasty. The pulmonary function changes caused by polymethylme-thacrylic bone cement filling, especially the elderly bone injury patients, should be prevented and treated actively. OBJECTIVE： To observe the pulmonary function changes after bone injury treated with polymethylme-thacrylic bone cement filling. METHODS： Twenty-four patients with fractures and arthroplasty bone injury were selected from the Department of Orthopedics, Daqing Oilfield General Hospital between May 2010 and June 2011. The patients were treated with polymethylme-thacrylic bone cement filling. Vital capacity, forced vital capacity and maximum voluntary ventilation changes were compared after treated for 1 day and 1 week. RESUTLS AND CONCLUSION： For the patients with fractures and arthroplasty bone injury after treated with polymethylme-thacrylic bone cement filling for 1 day, the vital capacity was （2.45±0.56） L, forced vital capacity was （2.20± 0.39） L and maximum voluntary ventilation was （50.9±23.9） L, which were lower than those after treated for I week. Polymethylme-thacrylic bone cement filling can affect the pulmonary function of the patients to some extent, and this change may relate＇with microvascular embolization caused by bone cement application. So pulmonary embolism should be prevented and treated through strengthen monitoring, and durgs application before and after treatment.

关 键 词：生物材料 生物材料学术探讨 聚甲基丙烯酸甲酯 骨水泥 骨损伤 骨折 关节置换 肺功能 肺活 量 通气量 

分 类 号：R318[医药卫生—生物医学工程]