朱砂七总蒽醌对S180荷瘤小鼠抗氧化活性的影响  

Study of total anthraquinone from Zhushaqi on the antioxidant activity influence in S180 bearing mice

作　　者：赵勤[1,2] 胡锐[2] 卫昊[2] 郭惠玲[2] 吕腾[2] 孙芳云[1] 

机构地区：[1]西藏民族学院,咸阳712082 [2]陕西中医学院,咸阳712046

出　　处：《中药药理与临床》2013年第2期72-74,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：陕西省教育厅专项科研计划项目(09JK414)

摘　　要：目的:观察朱砂七总蒽醌对S180荷瘤小鼠抗氧化能力的影响。方法:建立S180小鼠动物模型,分为空白对照组、模型组、环磷酰胺对照组、朱砂七大、中、小剂量组,每天灌胃1次,连续治疗10天后,取瘤组织称其质量,计算抑瘤率,并检测各组荷瘤小鼠血清中超氧化歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、乳酸脱氢酶(LDH)活性和脂质过氧化物(MDA)含量。结果:朱砂七总蒽醌1.2、0.6、0.3 g/kg对S180荷瘤小鼠的肿瘤组织有明显抑制,抑制率为52.6%,39.85%和38.8%;朱砂七总蒽醌各剂量组能明显提高荷瘤小鼠血清SOD、GSH-Px酶活性,降低LDH活性和MDA含量,与荷瘤组相比,1.2g/kg和0.6g/kg剂量组有显著和非常显著性统计学意义。结论:朱砂七总蒽醌可以抑制S180小鼠瘤组织生长,增强机体抗氧化能力可能是其抗肿瘤途径之一。Objective： To study the antioxidant capacity Of ZSQ in S180 bearing mice. Methods： To establish the S180 mice model and were ran- domly divided into five groups： a tumor control group, a cytoxan（CTX） group, an ZSQ high- dose group, an ZSQ middle - dose group and an ZSQ low - dose group, 10 mice in each one. On the llth day, all the mice were sacrificed and tumor tissue was collected for the anti- tumor rate and the determination of SOD,GSH-Px,LDH and MDA , etc. Results： ZSQ significantly inhibit the growth of $180 tumor in mice. The inhibitory rate was 52.6% ,39.85%, and 38.8%. Of all groups （1.2,0.6,0.3 g/kg）, SOD and GSH-Px activity was obviously increased, LDH and MDA content obviously decreased in the serum of S180 bearing mice. the antioxidant effect of in S180 mice were signifi- cantly improved. Compared with a tumor-burdened group, middle-dose and high-dose groups indicated significant statistical difference（ P 〈 0. 01 ,P 〈0.05）. Conclusion： ZSQ can inhibit the proliferation of tumor in S180 bearing mice. Strengthen the antioxidant effect may be its one way of antitumor.

关 键 词：朱砂七总蒽醌 S180瘤株 抑瘤率 抗氧化作用 

分 类 号：R285[医药卫生—中药学]