糖尿病心肌病的内质网病变机制及六味地黄汤的治疗作用  

Endoplasmic reticulum lesions in diabetic cardiomyopathy and Liuweidihuang Decoction treatment

作　　者：李梦[1] 戴德哉[1] 于锋[1] 戴茵[1] 

机构地区：[1]中国药科大学药理研究室,南京210009

出　　处：《中药药理与临床》2013年第2期196-198,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金资助项目(No:81070145)

摘　　要：糖尿病心肌病发病机制复杂,可涉及代谢紊乱、氧化应激、细胞凋亡、炎症反应、心肌钙调控紊乱等,其中内质网应激和钙调蛋白异常可能是糖尿病心肌病发生发展中重要的病理机制。六味地黄汤除了治疗肾虚、肾炎,临床上也有对高血压、心脑血管疾病、支气管感染、更年期综合征、糖尿病、抗肿瘤等方面的报道。本文主要介绍内质网病变与糖尿病心肌病的关系及六味地黄汤的治疗作用。The pathogenesis of diabetic cardiomyopathy is complex, involving metabolic disorders, oxidative stress, apoptosis, inflammation, myo- cardial calcium handling protein disorders, in which endoplasmic reticulum stress and calcium handling proteins abnormalities may be the key mechanism of diabetic cardiomyopathy. Liu Wei Di Huang is a classic recipe of traditional Chinese medicine, In addition to its effects on kid- ney deficiency and kidney inflammation, there are also some clinical reports on its effects on hypertension, cardiovascular and cerebrovascular diseases, bronchial infection, menopausal syndrome, diabetes, anticancer and so on.. In this review, we will focus on the endoplasmie retic- ulum lesions in diabetic eardiomyopathy and the effects of Liu Wei Di Huang decoction on cardiomyopathy.

关 键 词：六味地黄汤 糖尿病心肌病 内质网应激 钙调控蛋白异常 

分 类 号：R259[医药卫生—中西医结合]