开心散治疗老年性痴呆的研究进展  

The research progress in the study of Kaixin San in the treatment of senile dementia

作　　者：张博[1] 黄树明[1] 

机构地区：[1]黑龙江中医药大学中医药研究院,哈尔滨150040

出　　处：《中药药理与临床》2013年第3期193-196,共4页Pharmacology and Clinics of Chinese Materia Medica

基　　金：教育部高等学校博士学科点专项科研基金(No.20092327110008);黑龙江省自然科学留学归国人员基金(No.LC2008C26);黑龙江省教育厅海外学人资助项目(1153h18)

摘　　要：随着当今社会人口老龄化的加剧,老年性痴呆即阿尔茨海默病(Alzheimer's disease,AD)的罹患率呈极速上升趋势,已成为对人类危害最大的疾病之一。中医学对此病有良好的治疗效果,始见于唐代《备急千金要方》中的开心散就是治疗痴呆的典型方剂。近年来关于开心散治疗老年性痴呆的效果和机制有了大量的实验研究。本文从改善行为学表现、影响Aβ产生和分解、增强神经突触可塑性、保护神经元、抗氧化作用、抑制乙酰胆碱酯酶活性以及调节脑内NO含量等七方面对开心散防治老年痴呆的研究进展进行综述。With the aging population increase in the modem world, the incidence rate of senile dementia, also known as Mzheimer＇s disease （AD）, is uprising rapidly, and it has become one of the most harmful diseases to human being. This disease was known from thousands of years ago in Traditional Chinese Medicine as it was recorded in 《Bei Ji Qian Jin Fang》 written by Sun Simiao in Tang Dynasty. In order to treat this disease, the aLtthor created Kaixin San, a famous classic formula, and recorded it in his book. The main function of the formula is to treat ＂amnesia＂, which referred to senile dementia in the modern world. In this review, we will focus on Kaixin-san improving AD behavioral performance, affecting the production and membohsm of Aβ, enhancing the neuronal synaptic plasticity, protecting the neurons, playing a role on antioxidation, inhibiting the activity and expression of the AchE and regulating the level of NO.

关 键 词：开心散 淀粉样蛋白(Aβ) 阿尔茨海默病 

分 类 号：R277.7[医药卫生—中医学]