老年慢性阻塞性肺疾病急性加重患者单核细胞趋化蛋白-1、组织因子的临床意义  

Clinical significance of monocyte chemoattractant protein-I, tissue factor in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：王勇[1] 丁宁[1] 翟艳苓[2] 刘复强[2] 郑毅[1] 

机构地区：[1]首都医科大学附属北京同仁医院急诊科,100730 [2]首都医科大学附属北京同仁医院血液科,100730

出　　处：《中国医师进修杂志》2013年第19期1-3,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨老年慢性阻塞性肺疾病急性加重（AECOPD）患者单核细胞趋化蛋白（MCP）．1与组织因子（TF）水平及临床意义。方法老年AECOPD患者49例（AEc0PD组）和同龄健康志愿者30例（对照组），AECOPD组依据血清降钙素原（PCT）水平分为PCT增高组（PCT≥0．5μg.L，19例）和PCT正常组（PCT〈0．5μg／L，30例）。采用酶联免疫吸附法检测血浆TT和血清MCP-1。结果AECOPD组血浆TF、血清MCP-1水平分别为（203．6±92．9）、（152．8±99．9）ng／L，显著高于对照组的（136．9±24.3）、（87．5±41．5）ng／L，差异有统计学意义（P〈0．01）；且血浆TF与血清MCP-1呈正相关（r=0．673，P=0．029）。PCT增高组血浆TF及血清McP．1水平分别为（215．3±71．2）、（181．1±61．6）ng／L，显著高于PCT正常组的（192．4±79．7）、（137．3±74．4）ng／L，差异有统计学意义（P〈0．05）。结论老年AECOPD患者存在激活的高凝状态，PCT增高者更严重。老年AECOPD患者血浆TF与血清MCP-1水平有一定的相关性。监测血浆TF与血清MCP-1水平对老年AECOPD患者血液高凝状态及心、肺、脑等血栓性疾病的防治有重要意义。Objective To investigate the levels and clinical significance of monocyte chemoattractant protein （MCP）-1 and tissue factor （TF） in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods Forty-nine elderly patients with AECOPD（AECOPD group） and 30 healthy controls（control group） were selected,and AECOPD group was divided into preealcitonin （PCT） increased group（PCT〈 0.5μg/L g/L, 19 cases） and PCT normal group（PCT 〈 0.5 μ g/L, 30 cases） according to the level of serum PCT. The levels of plasma TF, serum MCP-1 and PCT were determined by enzyme linked immunosorbent assay. Results The levels of plasma TF and serum MCP-1 were （203.6 ± 92.9）, （ 152.8 ± 99.9） ng/L in AECOPD group, and （136.9 ±24.3）, （87.5 ±41.5） ng/L in control group. There were significant differences in the levels of plasma TF and serum MCP-1 between AECOPD group and control group （P 〈 0.01）. The level of plasma TF was positively correlated with serum MCP-1 （r = 0.673,P = 0.029）. The levels of plasma TF and serum MCP-1 were （215.3 ±71.2）, （181.1±61.6） ng/L in PCT increased group, and （192.4 ±79.7）, （137.3 ±74.4） ng/L in PCT normal group. There were significant differences in the levels of plasma TF and serum MCP- I between PCT increased group and PCT normal group（P 〈 0.05）. Conclusions In patients with AECOPD, hypercoagulability state is activated, and it is more severe in the patients with increased PCT. The level of plasma TF is positively correlated with serum MCP-1 in patients with AECOPD. To monitor the levels of plasma TF and serum MCP-1 is particularly important for elderly patients of AECOPD with hypercoagulability state to prevent cardiovascular, lungs and cerebrovascular thrombotic disease.

关 键 词：肺疾病 慢性阻塞性 凝血致活酶 单核细胞化学吸引蛋白质类 降钙素原 

分 类 号：R563.9[医药卫生—呼吸系统]