鼻内镜低温等离子辅助下鼻窦手术联合抗真菌药物治疗真菌性鼻-鼻窦炎的疗效观察  

Observation on the effect of endoscopic sinus low-temperature plasma-assisted sinus surgery combined with antifungal drug in treatment of fungal nasal-sinusitis

作　　者：马祖国[1] 胡伟[1] 

机构地区：[1]阜阳市人民医院耳鼻咽喉-头颈外科,安徽省阜阳236000

出　　处：《中国基层医药》2013年第14期2117-2118,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察鼻内镜低温等离子辅助下鼻窦手术联合抗真菌药物对真菌性鼻-鼻窦炎的临床治疗效果。方法回顾性分析108例真菌性鼻．鼻窦炎患者的临床资料，所有患者采用鼻内镜低温等离子辅助下鼻窦手术治疗。根据术后抗真菌药物使用与否分为观察组和对照组，观察组56例，术后应用氟康唑等抗真菌药物；对照组52例，术后采用0．9％氯化钠溶液清洗。对两组患者进行6个月至2年的随访，比较两组治疗效果和复发情况。结果观察组56例患者，治愈49例，好转7例，无复发病例。对照组52例，治愈47例，好转4例，无效1例，复发3例。观察组复发率明显低于对照组，差异有统计学意义（X^2=4．82，P〈0．05）。结论鼻内镜低温等离子辅助下鼻窦手术联合抗真菌药物治疗真菌性鼻-鼻窦炎疗效确切，在预防和降低复发率上效果显著，可进行临床推广。Objective To study the clinical effect of surgery combined with antifungal drug in treatment of fungal nose-sinusitis. Methods The clinical data of 108 cases with fungal nose-sinusitis were retrospectively ana- lyzed. All patients were treated with nasal endoscopic sinus surgery. According to whether the patients received anti- fungal drugs after low-temperature plasma-assisted surgery, the patients were divided into the treatment group and the control group. The treatment group（56 cases） was given antifungal fluconazole after low-temperature plasma-assisted endoscopic sinus surgery. 52 cases in the control group were washed by 0.9% sodium chloride solution after conven- tional endoscopic sinus surgery. The patients were followed up for 6 months to 2 years, the therapeutic effect and recur- rence were compared between the two groups. Results 56 patients of the treatment group,49 cases were cured,7 ca- ses improved,no recurrence. 52 cases in the control group,47 cases were cured,improved in 4 cases,ineffective in 1 case,3 cases of recurrence. The recurrence rate of the treatment group was significantly lower than the control group （ X^2 = 4.82,P 〈 0.05）. Conclusion The low-temperature plasma-assisted surgery combined with antifungal drug in the treatment of fungal nose-sinusitis has exact efficacy, and has significant effect on the prevention and reduce the relapse rate, which worthy of clinical promotion.

关 键 词：耳鼻喉外科手术 抗真菌药 鼻窦炎 

分 类 号：R765[医药卫生—耳鼻咽喉科]