某院130例药品不良反应报告的分析  

Analysis of 130 ADR Cases in the Maternal and Child Health Hospital of Hunan Province

作　　者：江慧星[1] 肖凯[1] 田霞[1] 欧阳波[1] 

机构地区：[1]湖南省妇幼保健院药学部,湖南长沙410008

出　　处：《中国医药指南》2013年第16期34-35,共2页Guide of China Medicine

摘　　要：目的了解我院药品不良反应(ADR)发生的特点,促进临床合理用药。方法收集我院2012年1～12月130例ADR报告进行统计分析。结果静脉给药发生ADR101例;子宫腔内给药引起ADR 5例。丙泊酚注射液静脉麻醉时,发生皮肤红斑、红疹67例,其中2例发生严重ADR。抗菌药物26例;妇产科等性激素类药物9例;维生素及微量元素类药物8例。结论 2012年抗菌药物ADR发生率较2007年下降62.86%,随着其使用量的减少,ADR发生率也大幅下降。针对我院专科特点,应加强静脉用麻醉药、妇产科等性激素类、维生素及微量元素类药物、止血药、口服中成药等ADR的监测,尽量减少静脉给药,关注子宫腔内注射给药引起的ADR。应按照说明书合理使用每一种药品,保证用药安全。Objective To understand the characteristics of adverse drug reaction （ADR） of authors＇ hospital, to stipulate the rational drug usage in clinic. Methods 130 ADR eases of authors＇ hospital, dated from January to December of 2012, have been collected and analyzed. Result 101 ADR cases are caused by intravenous injection; 5 ADR eases are caused by uterine cavity; 67 cases are caused by intravenous anesthetic propofol injection which leads to the occurrence of skin erythema, including two cases of serious ADR; There are 26 eases of antimierobial agents; there are 9 eases of obstetrics and gynecology and other hormone related drugs; there are 8 cases of vitamins and tiny elements of drugs eases, and so on. Conclusion Compared to 2007, the antimierobial ADR incidence rate decreased by 62.86 percent in 2012. While usage of antimicrobial drugs reduces, the ADR incidence also declined substantially. According to the characteristics of authors＇ hospital profession, ADR monitoring should be strengthened on the usage of intravenous anesthetics, obstetrics and gynecology, sex hormones, vitamins and tiny elements of drugs, hemostatie, oral proprietary. It is better to minimize intravenous injection, to concern about the uterine cavity injection to drugs which leads to ADR. It is important to keep rational and safe usage on drug in accordance with the instructions.

关 键 词：药品不良反应(ADR) 静脉麻醉药 抗菌药物 腔内注射 

分 类 号：R969.3[医药卫生—药理学]