灯盏花素与激素及环磷酰胺联合应用治疗活动性狼疮肾炎的疗效观察  

The Curative Effect Observation for Breviscapine Combined with Glucocorticoid and Cyclophosphamide in the Treatment of Activity Lupus Nephritis

作　　者：曾昭球[1] 

机构地区：[1]广东省第二人民医院风湿免疫科,广东广州510317

出　　处：《中国医药指南》2013年第16期448-449,共2页Guide of China Medicine

摘　　要：目的探讨灯盏花素与激素及环磷酰胺联合应用治疗活动性狼疮肾炎(LN)的临床疗效。方法将48例患有活动性狼疮肾炎患者随机分为治疗组和对照组,每组24例。治疗组采用常规环磷酰胺冲击治疗及激素标准疗程,同时合并使用中药灯盏花素。对照组采用激素标准疗程及常规磷酰胺冲击治疗。观察两组患者治疗后临床疗效、实验室血清免疫指标及副作用等情况。结果治疗组总有效率为93.9%,对照组总有效率为72.7%,两组比较有统计学差异(P<0.05);治疗组核抗体转阴率高,尿蛋白及红细胞减少比例较对照组高;治疗组的病死率和副作用发生率明显低于对照组,两组比较有统计学差异(P<0.05)。结论灯盏花素与激素及环磷酰胺联合应用治疗活动性狼疮肾炎能够提高治疗效果、改善预后、减少副作用发生,患者预后良好,值得在临床推广应用。Objective To observe clinical efficacy of breviscapine combined with prednisone and cyclophosphamide （CTX） in treatment of active lupus nephritis （LN）. Methods 48 cases of LN were randomly divided into 2 groups. Control group was given conventional therapy of prednisone and cyclophosphamide （CTX）; treatment group was given conventional treatment and breviscapine.The clinical efficacy and side effects of drugs of these two groups were compared. Results The total effective rate of treatment group was 93.9%, and control group was 72.7%. The difference （P〈0.05） has statistical significance.The occurrence rate of side effects of the treatment group was significantly lower than that of control group （P〈0.05）. Conclusion Breviscapine in treatment of active LN can not only improve the efficacy, but also significantly reduce the toxic side effects of Westem medicine. It is worthy of clinical application.

关 键 词：灯盏花素 环磷酰胺 活动性狼疮性肾炎 

分 类 号：R593.242[医药卫生—内科学]