Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents  

作　　者：Ying Meng Guan Wang Yue Li Kuan Hou Yue Yuan Li-Juan Zhang Hong-Rui Song Wei Shi 

机构地区：[1]Key Laboratory of Structure-Based Drug Design and Discovery,Ministry of Education,Shenyang Pharmaceutical University [2]Key Laboratory for Molecular Enzymology and Engineering,Ministry of Education,Jilin University [3]Key Laboratory for Molecular Enzymology and Engineering.Ministry of Education,Jilin University

出　　处：《Chinese Chemical Letters》2013年第7期619-621,共3页中国化学快报（英文版）

摘　　要：A series of pyrrolo[1,2-a]pyrazinone compounds （Sa-gf） were synthesized, and their cytotoxic activity against SKOV-3, A549, HeLa cells in vitro were evaluated by the MTF method. Some of the compounds showed potential antitumor activity against three tumor cell lines. Among them, compounds 9c and 9d showed the most potent cytotoxic activity. The preliminary mechanism of action was discussed.A series of pyrrolo[1,2-a]pyrazinone compounds （Sa-gf） were synthesized, and their cytotoxic activity against SKOV-3, A549, HeLa cells in vitro were evaluated by the MTF method. Some of the compounds showed potential antitumor activity against three tumor cell lines. Among them, compounds 9c and 9d showed the most potent cytotoxic activity. The preliminary mechanism of action was discussed.

关 键 词：Pyrrolopyrazinone Antitumor Synthesis 

分 类 号：TQ463.5[化学工程—制药化工]