Design,synthesis and screening of some novel benzoxazole based 1,3,4-oxadiazoles as potential antimicrobial agents  

作　　者：Sunil Vodela Raghu Vardhan Reddy Mekala Ravinder Reddy Danda Venkateshwarlu Kodhati 

机构地区：[1]Talla Padmavathi College of Engineering,Somidi,Kazipet 506003,Andhra Pradesh,India [2]Department of Chemistry,Kakatiya University,Warangal 506009,Andhra Pradesh,India [3]Department of Chemistry,Mahathma Gandhi University,Nalgonda 508254,Andhra Pradesh,India [4]Vaagdevi College of Pharmacy,Ramnagar,Hanamkonda 506001,Andhra Pradesh,India

出　　处：《Chinese Chemical Letters》2013年第7期625-628,共4页中国化学快报（英文版）

摘　　要：A series of novel 2-（5-substituted-[ 1,3,4]oxadiazol-2-yl）-benzoxazoles （Ta-h） were synthesized in good yields in two different directions by involving benzoxazole-2-carboxylic acid （1） as raw material and benzoxazole-2-carbonyl chloride （2）, benzoxazole-2-carboxylic acid methyl ester （3）, benzoxazole-2- carboxylic acid hydrazide （4）, benzoxazole-2-carboxylic acid N＇-acetyl hydrazide （Sa-d） and benzoxazole-2-carboxylic acid-ethylidene-hydrazides （6a-d） as reactive intermediates. The chemical structures of all the synthesized compounds were elucidated by their IR, 1H NMR and 13C NMR and mass spectral data. Further, the target compounds were screened for their antimicrobial activity against various Gram-positive and Gram-negative bacteria.A series of novel 2-（5-substituted-[ 1,3,4]oxadiazol-2-yl）-benzoxazoles （Ta-h） were synthesized in good yields in two different directions by involving benzoxazole-2-carboxylic acid （1） as raw material and benzoxazole-2-carbonyl chloride （2）, benzoxazole-2-carboxylic acid methyl ester （3）, benzoxazole-2- carboxylic acid hydrazide （4）, benzoxazole-2-carboxylic acid N＇-acetyl hydrazide （Sa-d） and benzoxazole-2-carboxylic acid-ethylidene-hydrazides （6a-d） as reactive intermediates. The chemical structures of all the synthesized compounds were elucidated by their IR, 1H NMR and 13C NMR and mass spectral data. Further, the target compounds were screened for their antimicrobial activity against various Gram-positive and Gram-negative bacteria.

关 键 词：Benzoxazoles 1 3 4-Oxadiazoles Antimicrobial activity 

分 类 号：TQ463.5[化学工程—制药化工]