奈达铂致过敏性休克1例  

Nedaplatin Induced Allergic Shock: Case Report

作　　者：王宇[1] 郭凯龙[1] 杨珺[1] 

机构地区：[1]中国医学科学院肿瘤医院药剂科,北京100021

出　　处：《药品评价》2013年第12期42-43,共2页Drug Evaluation

摘　　要：1例49岁男性患者,因食管癌实施放化疗同步治疗,连续放疗11次,第二次行紫杉醇+奈达铂化疗方案时,奈达铂静脉给药5min后出现心慌、憋气、脸红等症状。立即停止给药,给予对症处理,随后接连出现顽固性低血压及意识丧失等休克症状,对症处理后症状好转,心电图显示窦性心律、T波改变,治疗后心电图恢复正常。奈达铂不良反应发生率虽不高,但我院发生此例过敏性休克患者症状较为严重,应该引起临床的足够重视。Synchronous radiotherapy and chemotherapy was implemented on a 49-year-old male patient with esophageal carcinoma. Eleven times of continuous radiotherapy were followed by paclitaxel and nedaplatin chemotherapy. In the second chemotherapy, symptoms of palpitation, breath shortness and blush occurred five minutes after nedaplatin intravenous administration. Drug administration was immediately stopped, symptomatic treatment was given. Soon after, symptoms of shock as refractory hypotension and loss of consciousness occurred and showed sinus rhythm and T wave changes. Symptomatic treatment was given again, and ECG returned to normal after the treatment. Adverse reaction rate of nedaplatin is low, but patient in this case of allergic shock showed serious symptoms which worth enough attention in clinic.

关 键 词：奈达铂 药物不良反应 过敏性休克 

分 类 号：R593.1[医药卫生—内科学]