云南彝族人群与艾滋病相关SDF1-3’A、CCR2-64I、CX3CR1基因多态性研究  

The gene-polymorphism of HIV-1 resistant SDF1-3’A,CCR2-64I,CX3CR1 alleles in Yunnan Yi population

作　　者：徐文波[1] 年士艳[1] 张兴锋[1] 冯磊[1] 

机构地区：[1]玉溪市人民医院检验科,云南玉溪653100

出　　处：《中国优生与遗传杂志》2013年第7期8-10,共3页Chinese Journal of Birth Health & Heredity

基　　金：云南省科技厅面上资助项目编号:2008ZC150M

摘　　要：目的探讨云南彝族人群与艾滋病感染相关的SDF1-3’A、CCR2-64I、CX3CR1基因多态性分布。方法通过MassARRAY检测技术分析了96例云南彝族人群SDF1-3’A、CCR2-64I、CX3CR1单核苷酸多态性,通过与国内外研究结果比较,探讨其特点。结果在SDF1-3’A位点上明显高于美国黑人和高加索人;在CCR2-64I位点上明显高于汉族、黎族、仫佬族、美国黑人和高加索人;在CX3CR1-V249I和CX3CR1-T280M位点,均明显低于高加索人。结论云南彝族人群对HIV-1感染具有较强的抵抗力,AIDS的发病进程较缓慢。Objective： To study the gene-polymorphism of HIV-1 resistant SDF1-3’ A,CCR2-64I,CX3CR1 alleles in Yunnan Yi populations.Methods： The polymorphisms of SDF1-3’ A,CCR2-64I and CX3CR1 alleles were analyzed through MassARRAY and compared with other studies.Result： It was higher than Caucasian and American black in SDF1-3’ A;It was higher than Han,Li,Mulao,Caucasian and American black in CCR2-64I;It was lower than Caucasian in CX3CR1.Conclusion： The Yi population of Yunnan had stronger protection against infection of HIV-1 and was not easy to develop into AIDS.

关 键 词：彝族 趋化因子受体2 基质细胞衍生因子 辅助受体 人类免疫缺陷病毒1 基因多态性 

分 类 号：R512.91[医药卫生—内科学]