玉林地区171对自然流产夫妇染色体核型分析  

In 171 couples with spontaneous abortion chromosome karyotype analysis

作　　者：邓国生[1] 张炬光[1] 何娟[1] 

机构地区：[1]广西壮族自治区玉林市妇幼保健院,广西玉林537000

出　　处：《中国优生与遗传杂志》2013年第7期61-62,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨自然流产与染色体核型异常关系。方法对171对自然流产夫妇的外周血行染色体核型检查统计染色体核型异常状况。结果 171对自然流产夫妇中,染色体核型异常共20例,染色体核型异常检出率5.87%(20342),20例异常核型中染色体罗伯逊易位4例(20%);相互易位3例(15%);染色体倒位7例(35%);嵌合体1例(5%);染色体多态5例(25%)。随自然流产次数的增加,核型异常所占比例增加,其构成比具有统计学意义。结论自然流产与孕妇夫妇染色体异常核型密切相关。Objective： To study the relationship between spontaneous abortion and abnormal chromosome karyotype.Methods： A total of 171 couples with spontaneous abortions in the peripheral slices karyotype chromosome abnormal status statistics.Results： In 171 couples with spontaneous abortion,abnormal chromosome karyotype in 20 cases,abnormal chromosome karyotype detection rate was 5.87%（20 / 342）,In 20 patients with abnormal karyotype of chromosome translocation in 4 robersonian translocation（20%） robertson;3 cases of reciprocal translocation（15%）;Chromosomal inversions in 7 cases（35%）;mosaic in 1 cases（5%）;Chromosome polymorphism in 5 cases（25%）.With the increase of times of spontaneous abortion,karyotypic abnormalities in the proportion of the increase,the proportion had statistical significance.Conclusion： spontaneous abortion pregnant women and couples with chromosomal abnormalities are closely related.

关 键 词：自然流产 染色体 核型 

分 类 号：R714.21[医药卫生—妇产科学]