不同民族孕妇、新生儿脐血的微量元素与子痫前期的相关性分析  

correlation analysis of trace elements of different ethnic pregnant women and neonates with preeclampsia

作　　者：杜彦玫[1] 隋霜[1] 宋小平[1] 

机构地区：[1]新疆自治区人民医院产科,乌鲁木齐830001

出　　处：《中国优生与遗传杂志》2013年第7期82-84,共3页Chinese Journal of Birth Health & Heredity

基　　金：新疆维吾尔自治区人民医院院内项目编号:(20060203)

摘　　要：目的通过分析维汉两个不同民族孕妇血清与新生儿脐血钙(Ca)、镁(Mg)、铜(Cu)、锌(Zn)、铁(Fe)5种微量元素含量的差异性,以及微量元素的差异与子痫前期病情轻重的的相关性。方法选择维汉两族正常晚期妊娠者分别56、56例、子痫前期轻度患者分别72、60例、子痫前期重度患者分别52、66例,分别测定其母血及其对应的脐血的微量元素水平。结果汉族和维吾尔两组中的正常族、子痫前期轻度组、子痫前期重度组三组之间有差异(即A1、A2、A3和B1、B2、B3),且两两比较差异有统计学意义(P<0.05);通过Spearman相关分析,不同民族的母血中铁、钙、镁、铜、锌的含量与子痫前期的病情轻重有相关性,差别有统计学意义(P<0.05),且钙、镁、锌元素与子痫前期的病情呈负相关,铁、铜元素与子痫前期的病情呈正相关,不同民族的脐血中铁、钙、镁、铜、锌的含量与子痫前期的病情轻重同样具有相关性,差别有统计学意义(P<0.05),且各个元素作用的方向相同。结论子痫前期患者的钙、镁、锌含量较正常组低,而铁、铜的含量较正常组高,且两民族间存在一定的差异性;钙、镁、锌的含量越低,子痫前期的病情越重,铁、铜的含量越高,子痫前期的病情越重。Objective： To analyze the differences of trace elements of calcium（Ca）,magnesium（Mg）,copper（Cu）,zinc（Zn）,iron（Fe） between the two different ethnic maternal serum and cord blood,and analyze correlation between race elements differences and preeclampsia and the severity of the illness.Methods： Choose the Uygur and Han ethnic normal late pregnancy,respectively,56 and 56 cases of patients,and mild preeclampsia respectively 72,60,severe preeclampsia respectively,52,66,measured their mother,blood and its corresponding umbilical blood level of trace elements.Results： The two groups of Han and Uygur family,there are differences between the three groups of normal group,mild preeclampsia group and severe preeclampsia group（ie,A1,A2,A3 and B1,B2,B3） and difference was statistically significant（P 0.05）;Spearman correlation analysis,there are the correlation of different ethnic groups in maternal plasma content of iron,calcium,magnesium,copper,zinc and preeclampsia severity,the difference was statistically significant（P 0.05）,and a negative correlation of iron,copper and preeclampsia condition and a positively correlated with calcium,magnesium,zinc and preeclampsia condition,the umbilical cord blood of different ethnic groups in iron,calcium,magnesium,copper,zinc with preeclampsia severity were the same correlation as maternal‘s,and the difference was statistically significant（P 0.05）.Conclusion： in preeclampsia group,the content of calcium,magnesium,zinc is lower than the normal group,and the higher content of iron,copper,than normal group,and there are some differences between the two nationalities;the lower levels of calcium,magnesium,zinc,sub,the more severe of the preeclampsia,the higher the content of iron,copper,and the more severe of the preeclampsia.

关 键 词：孕妇 脐血 微量元素 子痫前期 

分 类 号：R714.2[医药卫生—妇产科学]