近十年中医证候的代谢组学研究进展  

Research on Progress of Metabonomics of Traditional Chinese Medicine Syndromes in Recent Ten Years

作　　者：田鸿芳[1] 高树中[1] 马玉侠[1] 

机构地区：[1]山东中医药大学针灸推拿学院,山东济南250355

出　　处：《成都中医药大学学报》2013年第2期99-102,共4页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：国家重点基础研究发展"973"计划(编号:2007CB512703);国家自然基金面上项目(编号:30973789)

摘　　要：目的:介绍近十年来中医证候的代谢组学研究进展。方法:通过检索中国知网数据库近十年来中医证候的代谢组学研究应用的文献17篇,对其进行归纳总结。结果:代谢组学运用现代分析技术手段获得内源性代谢组信息以认识机体的整体功能状态,具有系统性、整体性、动态性的特点,与中医证候具有相通之处,能揭示中医证候的本质。目前应用代谢组学技术研究中医证候取得了全面性发展。在今后的研究中,应加强代谢组学对中医证候的临床研究,加大研究样本量,完善代谢检测技术,并结合其它系统生物学研究方法对同一证候进行多方位、多角度的研究,以期更全面、客观的反映中医证候的本质。结论:代谢组学应用于中医证候研究具有广阔的前景。Objective： To summarize the research on progress of metabonomics of traditional Chinese medicine syndromes in recent ten years.Methods： Search the CNKI database in recent ten years and summarize its 17 literatures about metabolic application of traditional Chinese medicine syndromes.Results： Metabonomics takes advantage of modern analysis technique to obtain endogenous metabolism group information thus to know the overall function of body.It has a systematic,holistic and dynamic characteristic and has similarities with TCM syndromes,thus can reveal the essence of TCM syndromes.The application of metabonomics study of TCM syndromes has made comprehensive development in recent ten years.In future studies,we should strengthen the metabonomics in clinical study of TCM syndrome,increase the sample size of the study,improve and perfect metabolism detection technology and combine with other systems biology research methods to study the same syndrome on multi-direction and multi-angle,in order to reflect the essence of TCM syndromes more comprehensively and more objectively.Conclusion： Metabonomics has a vast potential for future application in the research of TCM syndromes.

关 键 词：代谢组学 中医证候 研究进展 

分 类 号：R241[医药卫生—中医诊断学] R3[医药卫生—中医临床基础]