从神经突触可塑性探讨电针治疗抑郁症的机制  

Principle Discussion of Utilizing Synaptic Plasticity Characteristics in Applying Depressive Disorder Treatment of Electric Acupuncture

作　　者：陈喆思[1] 郑重[2] 张虹[1] 邹可[2] 彭玉琳[1] 

机构地区：[1]成都中医药大学针灸推拿学院,四川成都610072 [2]四川大学华西医院,四川成都610041

出　　处：《成都中医药大学学报》2013年第2期113-116,共4页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(编号:30770778)

摘　　要：由于社会竞争的日益加剧,抑郁症患者逐年攀升,目前已成为当代医学研究的热点,其核心症状为学习及记忆能力的减退。临床电针治疗抑郁症疗效确切,且无副作用,其机理与神经突触的可塑性有着密切联系。神经突触可塑性分为形态可塑及功能可塑,长时程增强(LTP)、长时程抑制(LTD)作为突触可塑性的主要表现形式,参与学习、记忆的改善。通过综述电针对神经突触LTP、LTD的诱导及对突触形态的可塑探讨了电针治疗抑郁症的机制,并从"突触再可塑"阐述了电针对重复经颅磁刺激(rT-MS)的增效作用。The number of depressive disorder patients is increasing yearly due to growing competitions in all forms in society.It has become the focal point of current clinical research which the key symptom is decaying capability in learning and memory.Clinical curative effect for the treatment of depression has been proven effective and without side-effect,its principle is closely related to the synaptic plasticity.The synaptic plasticity consists of synaptic morphological plasticity and synaptic functional plasticity.LTP（Longterm Potentiation） and LTD（Long-term Depression）,being two major representations of synaptic plasticity,take part in improving learning and memory.This article discussed the principle of electric acupuncture treatment of depression by researching through the electricity for the synaptic LTP,LTD induction and the morphological plasticity,and further elaborates the enhancing effect towards rTMS from the field of＂The remodeling of synaptic plasticity＂.

关 键 词：抑郁症 电针 突触可塑性 

分 类 号：R245.3[医药卫生—针灸推拿学] R749.4[医药卫生—中医临床基础]