Ghrelin基因产物及其功能的多样性  

The Diversity of Ghrelin Gene in Its Products and Functions

作　　者：唐红[1] 张炜真[1] 

机构地区：[1]北京大学医学部基础医学院生理与病理生理系,北京100191

出　　处：《生理科学进展》2013年第3期169-176,共8页Progress in Physiological Sciences

基　　金：国家自然科学基金(81030012;30971434)资助课题

摘　　要：Ghrelin基因能通过选择性剪切和翻译后修饰生成多种产物,如酰基化acyl-ghrelin、非酰基化des-acyl-ghrelin、obestatin等,其功能包括促进生长激素释放、调节摄食和糖脂代谢、保护心肌和血管内皮细胞、调节免疫和炎症反应等。本文介绍了ghrelin基因的多种产物,重点讨论acyl-ghre-lin、des-acyl-ghrelin和obestatin的功能。By alternative splicing and posttranslational modification, ghrelin gene encodes multiple prod- ucts ranging from acyl-ghrelin, des-aeyl-ghrelin, to obestatin. These products exhibit diverse functions such as stimulating growth hormone secretion, regulating food uptake, glucose and lipid metabolism, pro- tecting cardiovascular system, and modulating immune and inflammation. This review summarizes the re- cent advances on the products of ghrelin gene and their diverse functions.

关 键 词：acyl-ghrelin des-acyl-ghrelin OBESTATIN 生长激素促泌素1a型受体 

分 类 号：R335[医药卫生—人体生理学]