小桃儿七中的1个新化合物  

A new compound from roots and rhizomes of Helleborus thibetanus

作　　者：王盈[1,2] 苏艳芳[1,3] 杨凤英[1] 颜世伦[1] 张肖[1] 

机构地区：[1]天津大学药物科学与技术学院,天津300072 [2]天津生物工程职业技术学院,天津300462 [3]天津中医药大学天津市中药化学与分析重点实验室,天津300193

出　　处：《中草药》2013年第13期1713-1716,共4页Chinese Traditional and Herbal Drugs

基　　金：教育部新世纪优秀人才支持计划资助项目(NCET-09-0589)

摘　　要：目的研究小桃儿七Helleborus thibetanus的化学成分。方法运用硅胶柱色谱及重结晶等方法进行分离纯化,根据理化性质和核磁共振波谱对化合物进行结构鉴定。结果从小桃儿七乙醇提取物中分离得到1个新化合物,鉴定为14β-羟基-3β-[(β-D-葡萄吡喃糖基)氧]-5α-蟾酥甾-20,22-二烯(1)。结论化合物1为新化合物,命名为铁筷子苷A,属于蟾蜍二烯羟酸内酯类强心苷类化合物。Objective To study the chemical constituents in the ethanol extract from the roots and rhizomes ofHelleborus thibetanus. Methods The compounds were isolated and purified by silica gel column chromatography and recrystallization. The structures of the compounds were identified on the basis of chemical and spectral methods. Results A new compound was isolated from the ethanol extract in the roots and rhizomes of H. thibetanus and identified as 14β-hydroxy-3β-[（β-D-glucopyranosyl）oxy]-5α-bufa-20, 22-dienolide （1）. Conclusion Compound 1 is a new compound named as hellebocoside A, which belongs to bufadienolide of cardiac glycosides.

关 键 词：小桃儿七 14β-羟基-3β-[(β-D-葡萄吡喃糖基)氧]-5α-蟾酥甾-20 22-二烯 铁筷子苷A 蟾蜍二烯羟酸内酯 强心苷 

分 类 号：R284.1[医药卫生—中药学]