Wnt信号通路与类风湿关节炎的相关性研究进展  

Relationship between Wnt signaling pathway and bone erosion in rheumatoid arthritis

作　　者：刘超 肖涟波 

机构地区：[1]上海中医药大学研究生院,上海201203 [2]上海市光华中西医结合医院骨科,上海200052

出　　处：《安徽医药》2013年第1期1-3,共3页Anhui Medical and Pharmaceutical Journal

基　　金：上海市科委资助项目(No 09411967400);上海市长宁区青年课题项目(No 20094Q03001)

摘　　要：类风湿关节炎(Rheumatoid Arthritis)是一种以慢性关节滑膜炎为主要特征的自身免疫性疾病,以形成侵袭性滑膜血管翳,破坏软骨、骨与周围组织为基本病理改变,发病2年内即可能出现全身性骨量减少及小关节的破坏,Wnt信号通路在在类风湿关节炎慢性炎症和骨质破坏的病理生理过程中起重要作用,研究Wnt信号通路作用,能为我们理解类风湿关节炎临床分型和预后提供理论依据,同时也能为类风湿关节炎的治疗提供新的研究方向。Rheumatoid arthritis（RA）is a chronic and progressive systemic inflammatory disease of unknown etiology.Primarily affecting the synovial membrane,RA can lead to bone and cartilage destruction.Other systems may also be occasionally affected.Recent studies have suggested that Wnt signaling pathway plays a role in the pathophysiology of RA.Greater knowledge of the role of the Wnt signaling pathway in RA could improve understanding of the differences in RA clinical presentation and prognosis.Further studies should also focus on Wnt family members as molecular targets in the treatment of RA.

关 键 词：类风湿关节炎 WNTS RANKL 破骨细胞 

分 类 号：R593.22[医药卫生—内科学]