骨疏灵颗粒提取工艺优化  

Optimization of extracting technology for gushuling granules

作　　者：朱裕林[1,2] 张冬梅[2] 王雷[2] 韩岚[2] 方清影[2] 方朝晖[3] 陈卫东[2] 

机构地区：[1]安徽省蚌埠医学院第一附属医院药剂科,安徽蚌埠233004 [2]安徽中医学院药学院,安徽合肥230031 [3]安徽中医学院第一附属医院,安徽合肥230038

出　　处：《安徽医药》2013年第6期909-911,共3页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省自然科学基金(No 1208085MH127)

摘　　要：目的优选中药复方制剂骨疏灵的提取工艺。方法采用正交试验设计,以淫羊藿苷和黄芪甲苷的提取率为评定指标,用多指标综合评分法进行数据处理,优化提取条件。结果优选出的提取条件为煎煮2次,每次1 h,第1次加水量为11倍,第2次加水量为8倍。结论优选得到的工艺稳定可行。Objective To optimize extraction technology of Gushuling, a compound preparation of Chinese medicine. Methods Orthogo- nal design was used to evaluate the icariin with astragaloside 1V extraction rate as indexes. Data processing was carried out with compre- hensive evaluation method for optimizing the extraction condition. Results Optimized extraction conditions were as follows：the drugs were decocted twice and 1 h per time; at first water was added to 1 t times and for the second time the amount of water was 8 times. Con- clusion The optimized technology is stable and feasible.

关 键 词：骨疏灵 淫羊藿苷 黄芪甲苷 正交设计 综合评分法 

分 类 号：TQ461[化学工程—制药化工] R286[医药卫生—中药学]