400例抗菌药物不良反应报告分析  

Adverse drug reaction analysis of 400 cases induced by antibacterial drugs

作　　者：储洁琼[1] 刘俊[1] 汪魏平[1] 

机构地区：[1]皖南医学院弋矶山医院药剂科,安徽芜湖241001

出　　处：《安徽医药》2013年第6期1076-1078,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨该院抗菌药物不良反应(ADR)发生规律及特点,为临床安全用药提供参考。方法对该院2010-2011年收集的400份抗菌药物ADR报告进行回顾性研究,登记ADR名称、级别、结果、药品名称、用药途径、患者年龄、性别、原患疾病。结果 ADR发生集中在40～50岁年龄段,但老年人及儿童发生ADR的比例也较高;其中,静脉滴注297例,占总数74.25%,口服给药96例,占总数24.00%;左氧氟沙星及阿奇霉素ADR发生比例高;ADR临床表现分布广泛,以皮肤及附件损害和消化系统症状为主。结论抗菌药物ADR产生原因较为复杂,广大医务工作者应加强抗菌药物监管,加大对ADR的认识,采取必要干预措施减少或避免ADR的发生。Objective To analyze the adverse drug reaction(ADR)induced by antibacterial drugs in Yijishan Hospital so as to provide reference for the safety use of drug in clinic.Methods A total of 400 ADR reported cases collected in our hospital from 2010—2011 were analyzed retrospectively,and we recorded the name of ADR,the level of ADR,the result of ADR,the name of drug,the route of administration,the age and the sex of patients and the name of disease.Results The age of patients were mainly in group 40~50,but the incidence of the elderly and the children were relatively high.Among the 400 ADR cases,297 ADR(74.25%)were caused by intravenous route of administration and 96 ADR(24.00%)were caused by oral.The ADR incidences of levofloxacin and azithromycin were high.ADR almost involved all the body system and mainly reflected in the injury of skin and digestive apparatus.Conclusion The reason of ADR induced by antibacterial drugs is complex.Clinical pharmacists should pay more attention to the management of antibiotics.Discovery and treatment is needed as to preventing or avoiding the occurrence of ADR.

关 键 词：抗菌药物 不良反应 分析 医院药学 合理用药 

分 类 号：R978.1[医药卫生—药品]