早期生活方式干预对骨量减低患者骨代谢指标的影响  

The change of bone metabolic markers in bone mass lose patients by early lifestyle intervention

作　　者：朱伟[1] 郑世霞[1] 

机构地区：[1]重庆市第三人民医院内分泌科,重庆400010

出　　处：《中国医药导报》2013年第21期152-154,共3页China Medical Herald

基　　金：重庆市卫生局项目(编号2012-2-226)

摘　　要：目的通过观察生活方式干预对骨量减低患者的骨代谢指标的影响,从而研究生活方式干预对骨质疏松的发生及发展的预防作用,为更早期防治骨质疏松提供理论依据。方法从2011年2～10月到重庆市第三人民医院体检中心进行健康体检的重庆地区人群,根据骨密度检查结果,共纳入84例骨量减低患者,随机分为生活方式干预组与对照组,生活方式干预组予以生活方式干预,而对照组与研究前生活方式保持不变,研究时间为1年。运用酶联免疫吸附法测定骨代谢标志物BAP和β-CTX,根据测定结果从而判定生活方式干预的效果。结果结果显示,干预前两组患者干预前后骨代谢标志物水平差异无统计学意义(P>0.05)。经过1年的干预研究,根据骨代谢指标的测定结果,两组各自的干预效果可明显看出:生活方式干预组干预1年后BAP[(17.406±0.388)μg/L]、β-CTX[(0.541±0.010)ng/mL]较干预前BAP[(26.123±0.086)μg/L]、β-CTX[(1.025±0.013)ng/mL]明显降低,较干预后对照组BAP[(26.570±0.382)μg/L]、β-CTX也明显降低[(1.027±0.055)ng/mL],差异均有高度统计学意义(均P<0.01)。结论生活方式干预能降低骨代谢标准物,从而明显降低骨转化率,因此在骨量减低期间进行生活方式干预能有效起到延缓骨质疏松发生发展的作用。Objective To observe the effect of lifestyle intervention on the change of bone metabolic markers in patients with bone mass loss, and explore the occurrence and development of osteoporosis preventive of lifestyle inter- vention, and thus provide theoretical basis for earlier prevention and treatment of osteoporosis. Methods February to October 2011 in the Medical Center of Chongqing of the Third People＇s Hospital of Chongqing, 84 patients who were diagnosed with bone mass lose were divided into intervention group and control group. Lifestyle intervention group received lifestyle intervention, while the control group remained unchanged lifestyle prior to the study. After 1 year, the BAP and β-CTX of bone metabolism markers were tested by enzyme-linked immunosorbent assay. The effect of lifestyle intervention were confirmed accorded to the bone mineral density test results.

关 键 词：骨量减低 生活方式干预 骨碱性磷酸酶 血清Ⅰ型胶原C端肽 

分 类 号：R163[医药卫生—公共卫生与预防医学]