阻塞性睡眠呼吸暂停低通气综合征患者血浆内脂素水平与颈动脉内膜中层厚度的关系  

Correlation between serum visfatin level and intima-madia thickness of carotid artery in patients with obstructive sleep apnea hypopnea syndrome

作　　者：阳书坤[1] 霍开秀[1] 徐福琴[1] 许梅妹[1] 王龙[2] 陈兰春[1] 

机构地区：[1]广东省深圳市龙岗区人民医院,518172 [2]兰州大学第一医院心内科

出　　处：《临床内科杂志》2013年第6期401-404,共4页Journal of Clinical Internal Medicine

摘　　要：目的 探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者血浆内脂素水平与颈动脉内中膜厚度的关系.方法 选择OSAHS患者62例和对照者30例,采用酶联免疫吸附法测定血浆内脂素水平,同时使用彩色多普勒超声检测颈动脉内膜中层厚度.结果 OSAHS患者血浆内脂素水平和颈动脉内膜中层厚度均高于对照组（P均＜0.01）.OSASH患者血浆内脂素水平与呼吸暂停低通气指数（AHI）呈正相关（r=0.541,P＜0.01）,与LSaO2和MSaO2均呈负相关（r分别为-0.502和-0.459,P均＜0.01）.颈动脉内膜中层厚度与AHI呈正相关（r=0.496,P＜0.01）,与LSaO2和MSaO2均呈负相关（r分别为-0.448和-0.511,P均＜0.01）.内脂素水平与颈动脉内膜中层厚度呈正相关（r =0.537,P＜0.01）.颈动脉内膜中层厚度与AHI、MSaO2和血浆内脂素水平呈线性回归关系.结论 OSAHS患者存在血浆内脂素水平升高和颈动脉内膜中层厚度增厚,与患者病情严重程度和低氧密切相关；内脂素是导致患者颈动脉内膜增厚的重要因素之一.Objective To investigate serum visfatin levels and the intima-madia thickness （IMT）of carotid artery in patients with obstructive sleep apnea hypopnea syndrome （OSAHS）.Methods 62 OSAHS patients（OSAHS group） and 30 healthy voluntrers（control group） were recruited in the study.The states of IMT of carotid artery were evaluated by ultrasonic imagingmethod and the levels of serum visfatin were test by enzyme-linked immunosorbent assay in both group.Results Compared to the control group,the levels of serum visfatin [（48.91 ± 12.39） vs.（33.89 ± 10.87） ng/ml] and were IMT of carotid artery [（1.14 ± 0.11） vs.（0.69 ± 0.09） mm] significantly higher in patients with OSAHS （P 〈0.01）.The level of serum visfatin levels and IMT of carotid artery were positive correlation to AHI（r =0.541,0.496 ;all P 〈 0.01）,which were negatively correlated to the LSaO2 and MSaO2 （r =-0.502,-0.459,-0.448,-0.511 ; all P 〈 0.01）.The level of serum visfatin and IMT of carotid artery was positively related（r =0.537,P 〈 0.01）.The IMT of carotid artery were in multiple linear regression with AHI,MSaO2 and serum visfatin level.Conclusion The level of serum visfatin was increased and the IMT of carotid artery are existed in OSAHS patients,and they are correlated to AHI and hypoxia during sleep.The visfatin was the important factors in OSAHS patients with carotid artery intimal thickening.

关 键 词：睡眠呼吸暂停低通气综合征 内脂素 颈动脉内膜中层厚度 

分 类 号：R766.43[医药卫生—耳鼻咽喉科]