右美托咪定预防胃癌根治术病人术后躁动的临床观察(英文)  

Effects of Dexmedetomidine on Restlessness in Patients Undergoing Radical Gastrectomy under General Anesthesia

作　　者：刘显珍[1] 褚海辰[1] 高洁[1] 冯伟[1] 温翠丽[1] 王士雷[1] 

机构地区：[1]青岛大学医学院附属医院麻醉科,山东青岛266011

出　　处：《现代生物医学进展》2013年第20期3958-3961,共4页Progress in Modern Biomedicine

基　　金：Natural Science Foundation of China(30972855)~~

摘　　要：目的:研究右美托咪定用于全麻下行胃癌根治术后躁动的镇静效果。方法:选择60例因胃癌需行全胃癌根治术的病人随机分为右美托嘧定组(D组)和安慰剂组(C组),每组30例。患者选用静脉复合全身麻醉,D组于术毕前半小时泵注右美托嘧定0.6μg/kg,10分钟泵完。C组以同样方式泵注生理盐水。术毕待患者呼吸恢复,清醒拔管。监测记录患者入室后(T0),拔管前(T1),拔管时(T2),拔管后5 min(T3)、拔管后15 min(T4)时的术中心率(HR)、平均动脉压(MAP),记录手术结束至拔管的时间,观察患者手术后躁动的次数和程度。结果:①两组患者性别、年龄、体质量、手术时间无显著差异。②C组T1,T2,T3,T4时间点MAP、HR值与T0比较有明显差异(P<0.05)。D组各时间点较T0无明显变化,D组HR,MAP较C组明显降低(P<0.05),③D组的拔管时间较C组长(P<0.05)。D组的躁动发生率明显低于C组(P<0.05)。结论:术毕前半小时泵注右美托咪定(10分钟泵完)可显著减少手术后躁动的发生,减少手术后呼吸抑制发生的可能性,保障了患者术后的安全。Objective： To investigate the preventive effect of intravenous injection of Dexmedetomidine on restlessness in patients undergoing radical gastrectomy under general anesthesia. Methods： 60 patients with gastric cancer were randomly divided into two groups （Dexmedetomidine, i.e. group D and group control, i.e. group C）. ASA I-II grade. Patients in both groups received by intravenous injection under general anesthesia. Half an hour before the end of operation, patients in DEX group were given 0.6 p^g/kg （finished in 10 min） through a minipump. Patients in the control group were offered normal sline as the same way for DEX group. The extent of restlessness at the time of patient arrived operating room（T0）, before tube removal（Tt）, immediately after tube removal（T2）, five minutes after tube removal （T3）, fifteen minutes after tube removal （T4）, the heart rate （HR）, mean arterial pressure （MAP）, extubation time were recorded. Results： （~The gender, age, time of surgery was no significant difference between the two group. @ Compared with those patients in control group, the HR and MAP of patients in DEX group were steady, and that at T1, T2, T3, T4 were lower （P〈0.05）. （~） The extubation time was longer （P〈0.05）; The incidence of restlessness was lower （P〈0.05）. Conclusion： The injection of DEX by using a minipump at half an hour before the end of operation （finished in 10 min） can relieve the incidence of restlessness and the probability of respiratory depression, and raise the safety of patients.

关 键 词：右美托咪定 胃癌根治术 术后躁动 全身麻醉 

分 类 号：R614.2[医药卫生—麻醉学] R735.2[医药卫生—外科学]