九节茶肿痛宁乳膏镇痛抗炎及皮肤刺激和过敏性作用  

Studies on the anti-inflammatory and analgesic effects and the safety of Sarcandra Zhongtongning cream

作　　者：欧余航[1] 李杰[1] 陈强[1] 

机构地区：[1]福建中医药大学,福建福州350122

出　　处：《中国医院药学杂志》2013年第14期1118-1121,共4页Chinese Journal of Hospital Pharmacy

基　　金：福建省科技厅重点项目(编号:2011I0003)

摘　　要：目的:对九节茶肿痛宁乳膏的镇痛抗炎作用进行了研究,并对其皮肤的刺激性和致敏性进行了初步评价。方法:以醋酸扭体法和二甲苯致耳肿胀实验研究九节茶肿痛宁乳膏的镇痛抗炎作用;通过对家兔皮肤刺激性实验、豚鼠皮肤过敏性实验对乳膏的安全性进行初步研究。结果:九节茶肿痛宁乳膏对二甲苯所致小鼠耳郭炎症和醋酸所致的腹痛有显著的抑制作用;对家兔皮肤无刺激性,对豚鼠也不引起过敏反应。结论:九节茶肿痛宁乳膏具有明显的镇痛抗炎作用,是一种安全性高的外用产品。OBJECTIVE To study the anti-inflammatory and analgesic effects of Sarcandra Zhongtongning cream and to evaluate preliminarily its irritation and allergic reaction on animal skin. METHODS The anti-inflammatory and analgesic effects of Sarcandra Zhongtongning cream were researched through xylene-induced auricle swelling experiment and acetic acid writhing method in mice. The experiment of irritation on the skin was studied in rabbits and the experiment of allergic reaction was stud led on the skin of guinea pig to evaluate the preliminary safety of the creams. RESULTS Sarcandra Zhongtongning creams possessed marked inhibitory effect on auricular inflammation caused by xylene and abdominal pain induced by acetic acid in mice. The results showed that there was no irritation on the skin of rabbits and no allergic reaction on the skin of guinea pigs. CONCLUSION Sarcandra Zhongtongning cream has obvious anti-inflammatory and analgesic effects. It is a kind of external product with high safety.

关 键 词：九节茶肿痛宁乳膏 镇痛 消炎 刺激性 过敏性 

分 类 号：R285.5[医药卫生—中药学]