流化床制备葡萄多酚微囊的工艺研究  

Study on the preparation technique of Grape Polyphenols Microcapsules with fluidized bed

作　　者：王爱霞[1] 金青[1] 尹文华 谭然然[1] 

机构地区：[1]青岛科技大学,青岛266042 [2]青岛市海泊河污水处理厂,青岛266021

出　　处：《西北药学杂志》2013年第4期403-405,共3页Northwest Pharmaceutical Journal

摘　　要：目的利用流化床的中试设备考察葡萄多酚微囊的制备工艺。方法以50mg·mL-1丙烯酸树脂S100的乙醇溶液为包衣液,采用底喷式流化床包衣技术制备葡萄多酚微囊。以包封率为指标,通过正交设计考察包衣液流速、雾化压力、进风压力和包衣温度4个因素对包封率的影响,并对所制微囊的稳定性进行考察。结果最佳的制备工艺是:流速0.25mL.min-1;雾化压力0.6bar;进风压力0.22bar;包衣温度30℃。制备成微囊后,葡萄多酚在光照、高温条件下的稳定性明显改善。结论优选出的制备工艺经验证可行、可靠。Objective To investigate the preparation process of Grape Polyphenols Microcapsules with the pilot equipment of fluidized bed. Methods 50 mg ·mL^-1 Eudragit S100 ethanol solution was chosen as the coating liquid,and the Grape Polyphenols Microcap- sules were prepared by using of the bottom spray fluidized bed. Encapsulating rate was used as an index in an orthogonal experi- ment design to choose the optimal coating liquid velocity , atomization pressure ,inlet air pressure and coating temperature,as well as to investigate the stability of the microcapsules. Results The optimal conditions were a coating liquid velocity of 0.25 mL ~ min-a , a atomization pressure of 0.6 bar,a inlet air pressure of 0. 22 bar,a coating temperature of 30 ℃. The stability at strong light and high temperature of the grape polyphenols was improved obviously. Conclusion The preparation technique was verified to be feasible and reliable.

关 键 词：葡萄多酚 微囊 流化床 

分 类 号：R944[医药卫生—药剂学]