全身炎症反应综合征病人CRRT后相关免疫和炎性指标的变化及意义  

CHANGES OF RELATED MARKERS OF SYSTEMIC INFLAMMATORY RESPONSE SYNDROM AFTER CONTINUOUS RENAL REPLACEMENT THERAPY

作　　者：衣沈妮[1] 胡丹[2] 尹海燕[3] 曲彦[2] 

机构地区：[1]青岛大学医学院,山东青岛266021 [2]青岛市市立医院东院ICU [3]山东大学齐鲁医院儿科

出　　处：《齐鲁医学杂志》2013年第3期247-249,252,共4页Medical Journal of Qilu

摘　　要：目的探讨全身炎症反应综合征(SIRS)病人连续性肾脏替代治疗(CRRT)后免疫和炎性相关指标的变化及其意义。方法 16例SIRS病人分别于CRRT治疗1、3d和治疗结束后采血,监测其C反应蛋白(CRP)、血常规、血气分析、APACHEⅡ评分和T细胞亚群的变化。结果 CRRT治疗后,CD3+、CD4+和NK值升高(F=3.333～6.768,P<0.05),CRP与APACHEⅡ评分均降低(F=4.887、8.591,P<0.01),而CD8+和CD4+/CD8+无明显变化。结论 CRRT可降低血浆CRP浓度,控制SIRS病人炎性反应,改善免疫功能及预后。Objective To investigate the changes of immune and inflammatory indexes in patients with systemic inflam- matory response syndrome （SIRS） after continuous renal replacement therapy （CRRT）. Methods C reactive protein （CRP）, blood count, blood gas, T cell subsets were detected in 16 patients with SIRS and APACHE ff scoring done-on days 1 and 3 and upon completion of therapy. Results AfterCRRT treatment, CD3＋, CD4＋ and NK increased （F=3.333--6.768,P〈0.05）, CRP and APACHE II score declined （F = 4.887,8.591;P 〈0.01）, no significant difference was found between CD8 ＋ and CD4＋ / CD8＋. Conclusion CRRT can reduce the concentration of plasma CRP, control the inflammatory reaction in patients with SIRS, and improve the immune function and prognosis.

关 键 词：全身炎症反应综合征 肾替代疗法 T淋巴细胞亚群 C反应蛋白质 

分 类 号：R459.5[医药卫生—治疗学]