3D ASL在急性轻度创伤性脑损伤中的应用  

Application of 3-dimensional Arterial Spin Labeling in Acute Mild Traumatic Brain Injury

作　　者：黄荣慧[1] 陈长青[1] 

机构地区：[1]中南大学湘雅医院放射科,湖南长沙410008

出　　处：《激光生物学报》2013年第2期174-179,共6页Acta Laser Biology Sinica

摘　　要：为了探讨3D动脉自旋标记(arterial spin labeling,ASL)技术对急性创伤性脑损伤(traumatic brain inju-ry,TBI)病人的诊断价值,将43例急性轻度TBI患者和20例健康志愿者进行了常规MRI(magnetic resonanceimaging)和3D ASL扫描。结果表明,3D ASL能显示常规MRI所不能显示的脑内血流灌注情况。3D ASL结果发现,健康志愿者组双侧前、中、后动脉供血区的脑血流量(cerebral brain flow,CBF)值比较均无差异(P值均>0.05);TBI患者未出现明显低灌注区的脑实质CBF较志愿者脑实质CBF值明显降低(P值<0.01);TBI患者脑内局部低灌注区较对侧镜面区的CBF值明显减低(P值<0.01)。3D ASL技术能检测出急性轻度TBI患者脑实质灌注减低情况,对于临床诊治有重要意义,值得在临床推崇。To investigate the diagnostic value of the 3-dimensional arterial spin labeling （3D ASL） technology in pa-tients with acute traumatic brain injury, conventional MRI and 3D ASL technology were employed to make brain scan for 43 patients with acute mild traumatic brain injury and 20 healthy volunteers. The results indicated that the status of cere-bral brain flow can be detected by 3D ASL rather than conventional MRI. The results from 3D ASL indicated that cere-bral brain flow （CBF） value is not obviously different among anterior, middle and posterior cerebral artery area from healthy people （P 〉 0. 05）. CBF value of TBI patients without distinct low hypoperfusion area was significantly lower than healthy peoples （ P 〈 0. 01 ）. CBF value of cerebral partial low hypoperfusion area of TBI patients was significantly lower than that of symmetrical side （P 〈 0. 01 ）. Hence it is worth to introduce 3D ASL technology to clinical applica-tion because the technology shows significant clinical value in detecting the status of low hypoperfusion area of CBF from acute mild TBI patients.

关 键 词：磁共振成像 动脉自旋标记 创伤性脑损伤 脑血管痉挛 脑缺血 

分 类 号：R445.2[医药卫生—影像医学与核医学]